5-Hydroxymethyltolterodine
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5-Hydroxymethyltolterodine
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CAS No:
207679-81-0
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Formula:
C22H31NO2
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Chemical Name:
5-Hydroxymethyltolterodine
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Synonyms:
Benzenemethanol,3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-;3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol;PNU 200577;5-Hydroxymethyltolterodine;(+)-N,N-Diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropylamine;Desfesoterodine;SPM 7605;(R)-(+)-2-(3-Diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol;2-[(1R)-3-[Di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol;156755-19-0
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CAS No:
Description
(R)-5-Hydroxymethyl Tolterodine(PNU-200577; Desfesoterodine) is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively. IC50 value: 0.84 nM (Kb)Target: mAChR(R)-5-Hydroxymethyl Tolterodine is a major pharmacologically active metabolite of tolterodine. In vitro, (R)-5-Hydroxymethyl Tolterodine prevented carbachol-induced contraction of guinea-pig isolated urinary bladder strips in a competitive and concentration-dependent manner. In viv
Desfesoterodine is a diarylmethane.|Desfesoterodine is a metabolite of [tolterodine].
5-Hydroxymethyltolterodine Basic Attributes
341.49
341.49
929-946-0
YU871O78GR
DTXSID40431319
G - Genito urinary system and sex hormones
2922509090
Characteristics
43.7
4.4
1.1±0.1 g/cm3
68-72°C
490.721°C at 760 mmHg
233.2±27.4 °C
1.563
-20°C Freezer
0mmHg at 25°C
Safety Information
Ⅲ
2811
6.1
P261, P264, P270, P272, P280, P301+P310, P301+P312, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P405, P501
H301
|Danger|H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P310, P301+P312, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, P405, and P501
Drug Information
5-Hydroxymethyl tolterodine is a known human metabolite of tolterodine.
(R)-N,N-diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropanamine
5-Hydroxymethyltolterodine Use and Manufacturing
A metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.
Computed Properties
Molecular Weight:341.5
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:341.235479232
Monoisotopic Mass:341.235479232
Topological Polar Surface Area:43.7
Heavy Atom Count:25
Complexity:357
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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