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Febantel

Febantel structure

CAS No:
58306-30-2
Formula:
C20H22N4O6S
Chemical Name:
Febantel
Synonyms:
Carbamic acid,N,N′-[[2-[(2-methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-,C,C′-dimethyl ester;Carbamic acid,[[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-,dimethyl ester;Febantel;Rintal;N-([[2-(2-Methoxyacetamido)-4-(phenylsulfanyl)phenyl]amino][(methoxycarbonyl)imino]methyl)carbamate
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly af

Febantel Basic Attributes

Molecular Weight：

446.48

Exact Mass：

446.48

EC Number：

261-205-0

UNII：

S75C401OS1

DSSTox ID：

DTXSID6046898

HScode：

2930902000

Characteristics

PSA：

153

XLogP3：

3.84990

Appearance：

white to off-white powder

Density：

1.3±0.1 g/cm3

Melting Point：

129.5 °C

Refractive Index：

1.598

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LD50: 10605 mg/kg; Oral-rabbit LD50: 1250 mg/kg

Flammability characteristics：

Flammable; heated to decompose toxic nitrogen oxides, sulfur oxides fumes

Collision Cross Section：

221.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|208.4 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

FB3955000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P273, P281, P301+P312, P308+P313, P330, P391, P405, and P501|Aggregated GHS information provided by 105 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)|Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)

MeSH Entry Terms：

2'-(2,3-bis(methoxycarbonyl)guanidino)-5'-phenylthio-2-methoxyacetanilide

Febantel Use and Manufacturing

Uses

Used as an anthelmintic

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Veterinary Drug -> ANTHELMINTHIC_AGENT; -> JECFA Functional Classes|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Food Additive Classes：

Veterinary Drug -> ANTHELMINTHIC_AGENT;

Computed Properties

Molecular Weight:446.5
XLogP3:3.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:446.12600561
Monoisotopic Mass:446.12600561
Topological Polar Surface Area:153
Heavy Atom Count:31
Complexity:621
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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