tert-Butyl acetate

116.15800

116.16

208-760-7

76N22HKP3X

1445

59719

1123

DTXSID1022055

Liquid|Colorless liquid

2915390090

26.30000

1.34800

Tert-butyl acetate is a colorless liquid with a mild odor. Floats on water. Produces irritating vapor. (USCG, 1999)

0.8593 g/cm³ @ Temp: 25 °C

<25 °C

97.8 °C

15ºC

1.385-1.387

Insoluble

Flammables area

Vapour pressure, kPa at 25°C: 6.3

Relative vapour density (air = 1): 4

LD50 orally in Rabbit: 4100 mg/kg

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

vol% in air: 1.5.3

Fruity odor

4.50e-13 cm3/molecule*sec

CONVERSION FACTORS: 4.74 MG/CU M IS EQUIVALENT TO 1 PPM|Softens or dissolves plastics|ODOR ... IS DETECTABLE IN WATER AT ... 4 PPB ...

Highly flammable. Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

TERT-BUTYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This compound is incompatible with the following: Nitrates; strong oxidizers, alkalis & acids (NIOSH, 2016).

799 °F (425 °C) /Butyl acetate/

% by vol: lower 1.5 (est)|Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

The vapour is heavier than air and may travel along the ground; distant ignition possible.

33.07 kJ/mol at bp; 39.03 kJ/mol at 25 °C

Critical temperature: 541 K; critical pressure: 3.0 MPa

III

3

UN 1123

1

R11; R66

S16-S23-S25-S29-S33

AF7400000

F

Fireproof. Separated from strong oxidants, strong bases and strong acids.

Heat /contributes to instability/.

P210

H225

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth, or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.

Contact with nitrates, strong oxidizers, strong alkalies, and strong acids may cause fires and explosions.|Nitrates; strong oxidizers, alkalis and acids.

Eighty organic cmpd, incl tert-butyl acetate, are discussed from the points of view of biological effects, toxicity (acute and subacute), genetic and carcinogenic effects. Each chapter is followed by a table summarizing toxicological data.[Damgard Nielsen G et al; Arbejdstilsynet, Arbejdsmiljoinstituttet, Rosenvaengets All'e 16-18, 2100 Kobenhavn N, Denmark, Aug 1982. 102 pages.]

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Highly flammable. Above 15.5 °C explosive vapour/air mixtures may be formed.|Flammable - 3rd degree

|Danger|H225 (97.56%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P312, P304+P340, P312, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 1269 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P312, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|Impervious clothing, gloves, and face shields and other protective clothing necessary to prevent repeated or prolonged skin contact with liquid tert-butyl acetate.|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|For more Personal Protective Equipment (PPE) (Complete) data for TERT-BUTYL ACETATE (8 total), please visit the HSDB record page.|(See protection codes)

Flammable.

Lower 1.5% (air)|Tert-butyl acetate should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.|Explosive limits , vol% in air: 1.5-7.3

To fight fire, use alcohol foam, CO2, dry chemical.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber.|/Absorbtion/ in vermiculite, dry sand, earth, or a similar material.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Employees should wash promptly when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard.|... A complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation. ... Clothing wet with liquid tert-butyl acetate should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of tert-butyl acetate from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the tert-butyl acetate, the person performing the operation should be informed of tert-butyl acetate's hazardous properties.|The worker should immediately wash the skin when it becomes contaminated.|For more Preventive Measures (Complete) data for TERT-BUTYL ACETATE (6 total), please visit the HSDB record page.

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Butyl acetates/|/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Butyl acetates/|/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Butyl acetates/|/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Butyl acetates/|For more DOT Emergency Guidelines (Complete) data for TERT-BUTYL ACETATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

... Exposures to concn of 200-300 ppm cause slight irritation of the eyes and nose, and short exposure to a concn of 3300 ppm cause extreme irritation of the eyes and nose.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 200 ppm (950 mg/cu m).

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 200 ppm (950 mg/cu m).

Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Separated from strong oxidants, strong bases and strong acids.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The vapour is irritating to the respiratory tract. The substance is mildly irritating to the eyes and skin. Exposure far above the OEL could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

NO open flames, NO sparks and NO smoking. Above 15.5 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles or eye protection in combination with breathing protection.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

INDOOR: Air samples were collected in 336 different industrial plants in Northern Belgium(1-2); 262 facilities contained one or more glycol esters; of these 262 facilities iso- or tert-butyl acetate was identified in 5% of operations using printing pastes and inks, 17% of those using paints and varnishes, 45% of car repair shops, and 30% of other industries(1,2).

tert-Butyl acetate occurs in bananas and related fruits(1) and may be released into the environment as a plant volatile(SRC).

tert-Butyl acetate's production and use as a solvent and gasoline additive(1,2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that tert-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of tert-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.1X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(3). tert-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 47 mm Hg at 25 °C(4). No biodegradation studies have been located for tert-butyl acetate, however, studies on structurally similar compounds(5-7) have shown that, in general, the ester functional group of alkyl acetates are biodegradable(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that tert-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.1X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5.5 hours and 5 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 7(SRC), from its log Kow of 1.76(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). No biodegradation studies have been located for tert-butyl acetate, however, studies on structurally similar compounds(8-10) have shown that, in general, the ester functional group of alkyl acetates are biodegradable(SRC). Hydrolysis is expected to occur slowly based upon experimentally determined hydrolysis half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively(11).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tert-butyl acetate, which has a vapor pressure of 47 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tert-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 36 days(SRC), calculated from its rate constant of 4.5X10-13 cu cm/molecule-sec at 25 °C(3). tert-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of tert-butyl acetate with photochemically-produced hydroxyl radicals has been reported as 4.5X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 36 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Based on experimentally determined acid-catalyzed hydrolysis rate constant of 1.26X10+4 L/mol-sec and base-catalyzed hydrolysis rate constant of 1.5X10-3 L/mol-sec at 20 °C(2), the hydrolysis half-lives of tert-butyl acetate at pH 7, 8, and 9 are 135, 14.6 and 1.5 years, respectively(SRC). tert-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 7 was calculated in fish for tert-butyl acetate(SRC), using a log Kow of 1.76(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tert-butyl acetate can be estimated to be 12(SRC). According to a classification scheme(2), this estimated Koc value suggests that tert-butyl acetate is expected to have very high mobility in soil.

The Henry's Law constant for tert-butyl acetate is estimated as 4.1X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tert-butyl acetate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 5.5 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). tert-Butyl acetate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). tert-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 47 mm Hg(3).

tert-Butyl acetate occurs naturally in bananas and other related fruits(1).

According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use for tert-butyl acetate is 100 to 999 persons; the data may be greatly underestimated(1).|Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where tert-butyl acetate is produced or used. The general population may be exposed to tert-butyl acetate through the ingestion of food sources such as bananas and other related fruits where it occurs as a natural constituent. (SRC)

Butyl acetates are readily hydrolyzed to acid and alcohol in blood, liver, small intestines and respiratory passages, and this has been demonstrated in vitro in homogenates. ... /butyl acetates/|A continuous 5 hr-exposure to approximately 440 ppm tert-butyl acetate in air (via a tracheal canule) resulted in continuously increasing concentrations of tert-butyl acetate and tert-butyl alcohol (metabolite of tert-butyl acetate) in the blood of rats. This accumulation of tert-butyl acetate and tert-butyl alcohol was reproduced during a continuous exposure to about 900 ppm tert-butyl acetate in air over a period of 4 hr and 15 min. After the inhalation approximately 50% of the blood level of tert-butyl acetate decreased within 45 min, but that of tert-butyl alcohol remained unchanged at a high level.

... When tert-butyl acetate was added to human blood samples the... /half-life/ was 300 minutes.

... /tert-Butyl acetate/ behaved as inhibitor of acetylcholine when it combined with the acetylcholine receptor on the muscle.

INHALATION: Irritation of throat. EYES: Irritation. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Esters and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

/HUMAN EXPOSURE STUDIES/ A study of sensory irritation (nasal pungency) associated with a series of homologous ketones and secondary and tertiary alcohols and esters was conducted. The study group consisted of three men and one woman, 41 to 65 years old, who lacked a sense of smell (anosmics) and three men and one woman 41 to 68 years old, with normal olfaction (normosmics). The subjects were exposed to 2-propanone (67641), 2-pentanone (107879), 2-heptanone (110430), 2-nonanone (821556), 2-propanol (67630), 2-methyl-2-propanol (75650), 2-butanol (78922), 4-heptanol (589559), tert-butyl-acetate (540885), and sec-butyl-acetate (105464) vapors at concentrations of 1x10-2 to 1x10+6 ppm by sniffing bottles containing the solvents. They also sniffed bottles containing a blank (nonodoriferous solvent). The subjects were asked to estimate the concentration of each solvent at which they could first detect the odor and perceive nasal pungency. Attempts were made to correlate the thresholds with the concentration of the saturated vapor at ambient temperature (23 °C). Both the normosmics and anosmics could detect the solvent vapors; however, the normosmics detected the vapors at much lower concentrations. The nasal pungency and odor thresholds of the ketones decreased with increasing carbon chain length, but tended to plateau at 2-heptanone. The odor and pungency thresholds of the alcohols tended to increase when the hydroxy group was changed from a primary to a secondary carbon atom. The odor and pungency thresholds of the esters were similar. When plotted against the logarithm of the saturation vapor concentration, the logarithm of the pungency thresholds of the compounds conformed to a linear function that was approximately parallel to the saturation vapor concentration. No association between odor threshold and saturation vapor concentration was seen. The authors conclude that anosmics as well as normosmics can detect odors of volatile organic compounds, although at different concentrations. The pungency threshold data suggest that physical rather than chemical factors are involved in the interaction of volatile organic compounds with the nasal mucosa.|/SIGNS AND SYMPTOMS/ ... Exposures to concn of 200-300 ppm cause slight irritation of the eyes and nose and short exposure to a concn of 3300 ppm cause extreme irritation of the eyes and nose.|/SIGNS AND SYMPTOMS/ Overexposure to tert-butyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness. Prolonged overexposure may produce irritation of the skin.|/SIGNS AND SYMPTOMS/ Acute human data /includes/ a report concerning exposure to polyester lacquer, with signs and symptoms manifested as nervous, respiratory, and cardiovascular system disorders.|For more Human Toxicity Excerpts (Complete) data for TERT-BUTYL ACETATE (8 total), please visit the HSDB record page.

tert-butyl acetate

The substance can be absorbed into the body by inhalation of its vapour.|inhalation, ingestion, skin and/or eye contact

Itch, inflammation eyes; irritation upper resp tract; headache; narcosis; dermatitis

Cough. Sore throat.

Dry skin.

Redness. Pain.

respiratory system, eyes, skin, central nervous system

TEXACO LEAD APPRECIATOR

Adhesive manufacturing|Acetic acid, 1,1-dimethylethyl ester: ACTIVE

Method: NIOSH 1450, Issue 3; Procedure: gas chromatography with flame ionization; Analyte: tert-butyl acetate; Matrix: air; Detection Limit: 0.9 ug/sample.|Method: OSHA 1009; Procedure: gas chromatography with flame ionization detector; Analyte: tert-butyl acetate; Matrix: air; Detection Limit: 29.7 picograms.|A gas chromatographic method for the analysis of n-butyl acetate, consists of a stainless steel column, 3 m x 3 mm, packed with Chromosorb WHP (100/120 mesh) coated with 5% FFAP, with hydrogen-air flame ionization detection, and nitrogen as the carrier gas at a flow rate of 30 mL/min, is a NIOSH approved method. A sample injection volume of 5 uL is suggested, the column temperature is 70 °C and a detector temperature of 250 °C. This method has a detection limit of 0.02 mg/L and a relative standard deviation of 0.02, over a working range of 95-2850 mg/cu m for a 10 liter sample.

Fire Hazards -> Flammable - 3rd degree