Polypropylene glycol

16.04246

134.094

200-338-0

WNY0H4G53Q

DTXSID9027863

Clear, lightly colored, slightly oily, viscous liquids

39072090

49.7

-0.7

White to light gray Viscous Liquid

1.002-1.007 g/cm³

50-70 °C

>300 °C

230 °C

/PPG 400/ Specific gravity: 1.007 at 25 °C; Pour point: -49 °C; Index of refraction: 1.445 at 25 °C|/PPG 750/ Specific gravity: 1.004 at 25 °C; Pour point: -44 °C; Index of refraction: 1.447 at 25 °C|/PPG 1200/ Specific gravity: 1.007 at 25 °C; Pour point: -40 °C; Index of refraction: 1.448 at 25 °C|/PPG 2000/ Specific gravity: 1.002 at 25 °C; Pour point: -30 °C; Index of refraction: 1.449 at 25 °C|/PPG 3000/ Specific gravity: 1.001 at 25 °C; Pour point: -29 °C; Index of refraction: 1.449 at 25 °C|/PPG 4000/ Specific gravity: 1.005 at 25 °C; Pour point: -26 °C; Index of refraction: 1.450 at 25 °C

Practically insoluble in water

<0.01 mm Hg ( 20 °C)

>1 (vs air)

Lower flammable limit: 2.6% by volume; Upper flammable limit: 12.5% by volume

Noncorrosive

/PPG 400/ Density: 1.01 g/mL at 20 °C; Index of refraction: 1.447 at 20 °C; Viscosity: approximately 100 mPa-sec at 20 °C|/PPG 1200/ Density: 1.00 g/mL at 20 °C; Index of refraction: 1.450 at 20 °C; Viscosity: approximately 270 mPa-sec at 20 °C|/PPG 2000/ Density: 1.00 g/mL at 20 °C; Index of refraction: 1.451 at 20 °C; Viscosity: approximately 450 mPa-sec at 20 °C|Does not crystallize

No rapid reaction with air. No rapid reaction with water.

Alcohols and Polyols

POLYPROPYLENE GLYCOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Lower flammable limit: 2.6% by volume; Upper flammable limit: 12.5% by volume

1

24/25

TR5250000

Stable. Substances to be avoided include strong oxidizing agents.

P264, P270, P280, P301+P310, P301+P312, P305+P351+P338, P321, P330, P337+P313, P405, P501

H301

SRP: Criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Spray into a furnace. Incineration will become easier by mixing with a more flammable solvent. Recommendable methods: Incineration.

Polypropylene glycol (minimum molecular weight 150) is an indirect food additive for use only as a component of adhesives.

USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Polypropylene Glycol. EPA 738-R-07-015 (September 25, 2007). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of October 7, 2009: http://www.epa.gov/pesticides/reregistration/status.htm]

|Danger|H301 (35.48%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P301+P312, P321, P330, P405, and P501|Aggregated GHS information provided by 2191 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Fire Extinguishing Agents: Water, dry chemical, foam, carbon dioxide (USCG, 1999)

Safety glasses or face shield; rubber gloves (USCG, 1999)

... Do not present hazards of flammability except at elevated temp ... Fire point (deg F OC): 405 /ppg 400/; 525 /ppg 750/; 505 /ppg 1200/; 510 /ppg 2000/; 505 /ppg 3000/; 510 /ppg 4000/ /From table/

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Mildly irritating to the eyes.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Polypropylene glycol is produced, as an intermediate or a final product, by process units covered under this subpart.

| 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Industrial exposure is most likely to be by direct contact with the skin and eyes. Ingestion should not be a problem except from an accident. The very low volatility of these materials makes inhalation improbable except perhaps where mists are formed from violent agitation or high temperatures ... No cases of toxicity have resulted from the manufacturing, handling, and use of polypropylene glycols.|NIOSH (NOES Survey 1981-1983) has statistically estimated that 217,886 workers (30,699 of these were female) were potentially exposed to polypropylene glycol in the US(1). Occupational exposure to polypropylene glycol may occur through inhalation where mists are formed from violent agitation or high temperatures, and dermal contact with this compound at workplaces where polypropylene glycol is produced or used(2).

3. 3 = moderately toxic: probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint (or 1 lb) for 70 kg person (150 lb).

Lower mol wt /PPG's (200-1200) ... are absorbed through the skin to some extent, /but/ skin penetration ... not ... serious industrial hazard ... These ... are not like low mol wt polyethylene glycols in their physiologic activity; they are rapidly absorbed from the GI tract ...|Acute skin absorption tests ... have indicated that the materials are all poorly absorbed through the skin.|/Male rats maintained for 100 days on diet containing 1.0% of P750/ ... postulated that material is readily metabolized or eliminated when absorbed in small doses; this probably accounts for its lack of apparent physiological effect.

The compound has a very low toxicity; few, if any, symptoms will be observed. Contact of liquid with eyes causes slight transient pain and irritation similar to that caused by a mild soap. (USCG, 1999)

EYES: flush with water until mild irritation is gone. (USCG, 1999)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ethylene glycol, glycols, and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethylene glycol, glycols, and related compounds/

/HUMAN EXPOSURE STUDIES/ P2000 is neither a skin irritant nor a skin sensitizer. This conclusion is based upon tests with the undiluted material conducted by both continuous and repeated application techniques on a total of 300 human subjects.|/SIGNS AND SYMPTOMS/ Low molecular weight polypropylene glycols (200 to 1200) have appreciable acute oral toxicity, are mildly irritating to the eyes, are not irritating to the skin, and although they are absorbed through the skin to some extent, skin penetration does not present a serious industrial hazard. The inhalation of mists or vapors from heated material, particularly low molecular weight material, could be hazardous. These materials ... are rapidly absorbed from the gastrointestinal tract, are potent CNS stimulants, and readily cause cardiac arrhythmias. The higher molecular weight materials whose average molecular weights are 2000 or more have very low toxicity by all routes and do not have the stimulant effect upon the CNS typical of the lower molecular weight materials.|/SIGNS AND SYMPTOMS/ ... /Low mol wt PPG's (200-1200)/ are not like low mol wt polyethylene glycols in their physiological activity; they are ... potent CNS stimulants and readily cause cardiac arrhythmias.

2-(2-hydroxypropoxy)-1-propanol

Of all polyether polyols (incl polypropylene glycol, polyethylene glycol, and propylene oxide-ethylene oxide copolymers), 65% were used in polyurethane flexible foam; 9% in polyurethane rigid foam; 7% in noncellular polyurethane applications; 8% for surface-active agents; 8% for lubricants and functional fluids; & 3% for misc applications (1976)|Annual: 16,533,333.33 lb; individual (human): 14.01129 mg/kg/day

Actocol 51-530|Bloat Guard|Desmophen 360C|Emkapyl|For more Formulations/Preparations (Complete) data for Polypropylene glycol (45 total), please visit the HSDB record page.

There are 2 active ingredients in reregistration case 3123 for polypropylene glycol. The RED evaluates the only active ingredient in this case with currently registered products; therefore, only butoxypolypropylene glycol (BPG), PC Code 011901/CAS No. 9003-13-8, 57 active products as of September, 2001/ was assessed. The other active ingredient in this case /poly(oxy(methyl-1,2ethanediyl)), alpha-hydro-omegahydroxy,CAS No. 25322-69-4 / has no product registrations /last pesticide product cancelled October 10, 1989/ and is not being supported for reregistration. This active ingredient would be evaluated only if and when new registration applications were to be submitted for new products.|One of a group of compd comparable to polyethylene glycols but more oil-soluble and substantially less water-soluble.

Method for determination of polypropylene glycol at sub-ppm levels in aqueous and organic media by gas-liquid chromatography or by gas chromatography-mass spectroscopy.

EPA Safer Chemical Functional Use Classes -> Solvents|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues|Cosmetics -> Emollient; Skin conditioning; Solvent