Flupirtine maleate
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Flupirtine maleate
structure -
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CAS No:
75507-68-5
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Formula:
C15H17FN4O2.C4H4O4
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Chemical Name:
Flupirtine maleate
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Synonyms:
Carbamic acid,N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-,ethyl ester,(2Z)-2-butenedioate (1:1);Carbamic acid,[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-,ethyl ester,(Z)-2-butenedioate (1:1);Carbamic acid,[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-,ethyl ester,(2Z)-2-butenedioate (1:1);Flupirtine maleate;W 2964M;Efiret;56995-21-2
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CAS No:
Description
Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.IC50 Value: Target: Potassium channel; NMDA receptorin vitro: High concentrations of flupirtine antagonized inward currents to NMDA(200 microM) at -70 mV with an lC50 against steady-state responses of 182.1+/-12.1 microM. The effects of flupirtine were voltage-independent and not associated with receptor desensitization making actions within the NMDA receptor chan
Characteristics
164
2.71190
white
1.35 g/cm3
175.5-176 °C
434.9ºC at 760 mmHg
216.8ºC
DMSO: soluble >20mg/mL
2-8°C
Safety Information
NONH for all modes of transport
3
22-24/25-35-20
EY8555800
P264, P270, P301+P312, P330, P501
H302
Flupirtine maleate Use and Manufacturing
Analgesic. Substituted pyridine with central analgesic properties.
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