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Flupirtine maleate

Flupirtine maleate structure

CAS No:
75507-68-5
Formula:
C15H17FN4O2.C4H4O4
Chemical Name:
Flupirtine maleate
Synonyms:
Carbamic acid,N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-,ethyl ester,(2Z)-2-butenedioate (1:1);Carbamic acid,[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-,ethyl ester,(Z)-2-butenedioate (1:1);Carbamic acid,[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-,ethyl ester,(2Z)-2-butenedioate (1:1);Flupirtine maleate;W 2964M;Efiret;56995-21-2
Categories:
Biochemical Engineering > Inhibitors

Description

Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.IC50 Value: Target: Potassium channel; NMDA receptorin vitro: High concentrations of flupirtine antagonized inward currents to NMDA(200 microM) at -70 mV with an lC50 against steady-state responses of 182.1+/-12.1 microM. The effects of flupirtine were voltage-independent and not associated with receptor desensitization making actions within the NMDA receptor chan

Flupirtine maleate Basic Attributes

Molecular Weight：

420.3916432

Exact Mass：

420.144501

EC Number：

278-225-0

HScode：

2942000000

Characteristics

PSA：

164

XLogP3：

2.71190

Appearance：

white

Density：

1.35 g/cm3

Melting Point：

175.5-176 °C

Boiling Point：

434.9ºC at 760 mmHg

Flash Point：

216.8ºC

Water Solubility：

DMSO: soluble >20mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25-35-20

RTECS Number：

EY8555800

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Flupirtine maleate Use and Manufacturing

Analgesic. Substituted pyridine with central analgesic properties.

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Flupirtine Maleate Capsules
Specifications	0.1 g

Flupirtine Maleate Capsules
Specifications	0.1g

Flupirtine Maleate Capsules
Ingredients	Flupirtine maleate.
Indication	Flupirtine maleate can enhance the effects of alcohol, some sedatives and muscle relaxants. Anticoagulants (e.g. coumarins such as warfarin) can have an enhanced effect under the action of flupirtine maleate. When patients take these drugs at the same time, they should often perform regular Quik's test to check the coagulation status. When flupirtine maleate is taken at the same time, the effect of diazepam may be increased. If flupirtine maleate is used together with some drugs that significantly affect liver metabolism, liver enzymes should be tested promptly and frequently. Flupirtine maleate should be avoided in combination with preparations containing paracetamol or carbamazepine. Do not drink alcohol while receiving drug treatment.
Specifications	0.1g

See More Related Drugs

Registered Holders

Sichuan Qingmu Pharmaceutical Co., Ltd.

China
Active
WISDOM PHARMACEUTICAL CO LTD

United States
Active
Reyoung Pharmaceutical Co., Ltd.

China
Inactive

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