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Oridonin

Oridonin structure

CAS No:
28957-04-2
Formula:
C20H28O6
Chemical Name:
Oridonin
Synonyms:
Kaur-16-en-15-one,7,20-epoxy-1,6,7,14-tetrahydroxy-,(1α,6β,7α,14R)-;Kaur-16-en-15-one,7α,20-epoxy-1α,6β,7,14-tetrahydroxy-,(14R)-;Oridonin;6,11b-(Epoxymethano)-6a,9-methano-1H-cyclohepta[a]naphthalene,kaur-16-en-15-one deriv.;(1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one;Isodonol;NSC 250682;Oridonine;(-)-Oridonin;18288-82-9;2305818-70-4
Categories:
Biochemical Engineering > Biosynthetic Natural Products

Description

Oridonin, a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

Oridonin Basic Attributes

Molecular Weight：

364.43

Exact Mass：

364.43

HScode：

2942000000

Characteristics

PSA：

107

XLogP3：

0.37560

Appearance：

powder

Density：

1.4±0.1 g/cm3

Melting Point：

248-250 °C

Boiling Point：

599.8°C at 760 mmHg

Flash Point：

215.0±23.6 °C

Refractive Index：

1.635

Water Solubility：

DMSO: >20mg/mL

Storage Conditions：

2-8°C

Vapor Pressure：

6.9E-17mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

36/37-24/25

RTECS Number：

NZ8177000

Marks：

Precautionary statement(s)：

P281

Hazard Statements：

H351

GHS Classification：

|Warning|H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

lasidonin

Computed Properties

Molecular Weight:364.4
XLogP3:0.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Exact Mass:364.18858861
Monoisotopic Mass:364.18858861
Topological Polar Surface Area:107
Heavy Atom Count:26
Complexity:717
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Rubescens rubescens slices
Ingredients	The auxiliary material is starch.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	-(Sugar-coated tablets); each tablet weighs 0.25g (film-coated tablets)
Manufacturer	BAO HE TANG(Jiaozuo) Co., Ltd.

Rubescens syrup
Ingredients	The auxiliary material is starch.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	100 ml per bottle
Manufacturer	Henan Jishi Pharmaceutical Co., Ltd.

Rabdosia rubescens capsule
Ingredients	The auxiliary material is starch.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.3g per tablet
Manufacturer	Henan Jishi Pharmaceutical Co., Ltd.

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Guide of Oridonin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Learn More Other Chemicals

Oridonin

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