3-Aminophenol Safety Data Sheets

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes and mucous membranes. ACUTE/CHRONIC HAZARDS: This chemical causes irritation of the eyes, skin and mucous membranes. When heated to decomposition it emits toxic fumes. (NTP, 1992)

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Spill handling: keep dust under control. Use a vacuum or wet method to reduce dust during clean-up. Do not sweep. Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection of your regional office of the federal EPA for specific recommendations. Aminophenols

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store in tightly closed containers in a cool, well-ventilated area. Aminophenols must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine), since violent reactions occur. Aminophenols

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

This compound may be sensitive to prolonged exposure to air and light. Slightly soluble in water.

no data available

M-AMINOPHENOL may react with strong oxidizers and mineral acids or bases. (NTP, 1992)

no data available

Strong oxidants. Aminophenols

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

Acute toxicity

• Oral: maximal non-lethal dose - rat (female) - > 500 mg/kg bw. Remarks:Based on overall effects.
• Inhalation: LC50 - rat - 1 162 mg/m³ air.
• Dermal: LD50 - Mammal - species unspecified - 6 400 mg/kg.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - 22.34 mg/L - 72 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 1.1 mg/L - 48 h. Remarks:Intoxication.
• Toxicity to algae: LDLo - Microcystis aeruginosa - 20 mg/L - 24 h.
• Toxicity to microorganisms: IC50 - Tetrahymena pyriformis - 361 mg/L - 40 h.

AEROBIC: 3-Aminophenol, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). 3-Aminophenol is generally resistant to biodegradation in a series of screening tests; 0% theoretical BOD was reached in a 14-day MITI test, 0% CO2 was reported over 28 days in the Sturm test, 7% dissolved organic carbon removal over 19 days was reported in a conventional OECD screening test and 0% theoretical BOD was reached in 30 days in a conventional closed bottle test(2). In the Zahn-Wellens test, 93% dissolved organic carbon removal was reported after 10 days while in a coupled units test, 94% dissolved organic carbon was removed after 14 days(2). When the inoculum was preacclimated, 97% dissolved organic carbon removal in 19 days was reported in the modified OECD screening test but only 1% theoretical BOD was reached in 30 days in the closed bottle test(3). A ring test using a respirometric method similar to the Modified MITI I method (OECD Method 310C) was conducted on 3-aminophenol; after 28 days, 6 of 12 laboratories reported 0% theoretical oxygen demand, with the remaining laboratories reporting mean and median of 5 and 27% theoretical oxygen demand, respectively(4). In a wastewater treatment simulation test with a 13-hour sewage retention time, 99% dissolved organic carbon removal was reported following a lag phase of 29 days(5).

BCFs of <4 and <40 in carp (Cyprinus carpio) were reported for a 6 week study using 1 and 0.1 mg/L 3-aminophenol, respectively(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 3-aminophenol can be estimated to be 90(SRC). According to a classification scheme(2), this estimated Koc value suggests that 3-aminophenol is expected to have high mobility in soil. However, anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be much lower in some soils(SRC). Measured pKa values are 4.37 and 9.815(5) for the amine and hydroxy functional groups, respectively(6). 3-Aminophenol is amphoteric and behaves either as a weak acid or weak base; the basic character usually predominates(7). At pH 7.7, 12% of added 3-aminophenol was sorbed by an organoclay(8).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/