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3-Aminophenol591-27-5

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CAS No.:

591-27-5

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

3-Aminophenol Basic information

Product Name:	3-Aminophenol
Synonyms:	1-Amino-3-hydroxybenzene;1-amino-3-hydroxybenzene[qr];M-HYDROXYANILINE;LABOTEST-BB LTBB000485;M-AMINOPHENOL;META AMINO PHENOL;3-AMINO-1-HYDROXYBENZENE;3-AMINOPHENOL
CAS:	591-27-5
MF:	C6H7NO
MW:	109.13
EINECS:	209-711-2
Product Categories:	Pyridines ,Halogenated Heterocycles;Organic Building Blocks;AM to AQChemical Class;A;Oxygen Compounds;Phenols;Aromatic Phenols;API intermediates;Organic Chemicals;A-BAlphabetic;Alpha sort;Amines;Aromatics;Pesticides&Metabolites;Anilines, Aromatic Amines and Nitro Compounds;Organics;Phenoles and thiophenoles;591-27-5
Mol File:	591-27-5.mol

3-Aminophenol Chemical Properties

Melting point	120-124 °C (lit.)
Boiling point	164 °C/11 mmHg (lit.)
bulk density	700kg/m3
density	0.99
vapor pressure	0.019Pa at 20℃
refractive index	1.5444 (estimate)
Fp	155 °C
storage temp.	2-8°C
solubility	26g/l
pka	4.37, 9.82(at 20℃)
form	Crystalline Powder
Colour Index	76545
color	White to pinkish or light gray
Odor	odorless
PH	6.8 (10g/l, H2O, 20℃)
Water Solubility	35 g/L (20 ºC)
Merck	14,460
BRN	636059
Henry's Law Constant	3.7×10⁴ mol/(m³Pa) at 25℃, HSDB (2015)
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, bases, mineral acids. May be light or air-sensitive.
Major Application	agriculture environmental
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	3-Aminophenol (591-27-5)
InChI	1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
InChIKey	CWLKGDAVCFYWJK-UHFFFAOYSA-N
SMILES	Nc1cccc(O)c1
LogP	0.183 at 20℃
CAS DataBase Reference	591-27-5(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 3-amino-(591-27-5)
EPA Substance Registry System	3-Aminophenol (591-27-5)

Safety Information

Hazard Codes	Xn,N
Risk Statements	20/22-51/53
Safety Statements	28-61-28A
RIDADR	UN 2512 (AMINOPHENOLS (o-, m-, p-))
WGK Germany	2
RTECS	SJ4900000
Autoignition Temperature	>600°C
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	III
HS Code	29222900
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Inhalation Acute Tox. 4 Oral Aquatic Chronic 2 Eye Irrit. 2
Hazardous Substances Data	591-27-5(Hazardous Substances Data)
Toxicity	LD50 i.p. in mice: 4.5 mg/20g (Koelzer, Giesen)

MSDS Information

Provider	Language
3-Aminophenol	English
SigmaAldrich	English
ACROS	English
ALFA	English

3-Aminophenol Usage And Synthesis

Chemical Properties	Light grey crystal powder
Chemical Properties	o-Aminophenol appears as colorless needles or as white crystalline substance turning tan to brown on exposure to air.
Uses	Dye intermediate, manufacture of p-aminosalicylic acid.
Uses	m-Aminophenol (MAP) is an important starting material for dyes, including a variety of leuco (or latent) dyes used in imaging technology, optical bleaches and fluorescent agents, drugs, agricultural chemicals; and high-performance polymers. Although the synthesis of m-aminophenol(s) by the reaction of resorcinol with ammonia or (di)alkylarnines has been known for about 100 years,the preferred manufacturing process had been for many years a route involving the sulfonation of nitrobenzene to m-nitrobenzenesulfonic acid, the reduction of the nitro group to give m-aminobenzenesulfonic acid, followed by the caustic fusion of sodium m-aminobenzenesulfonate to yield sodium m-aminophenolate. The m-aminophenol was isolated/purified by neutralization, filtration, and recrystallization; the overall yield of m-aminophenol from nitrobenzene was estimated by SRI International to be 58%. (Doubtless, process improvements were made by the producers using this process.) The nitrobenzene/sulfonationlreductionlcaustic fusion route is still being used commercially, notably by ACNA in Italy, the largest producer of MAP, as well as a few smaller manufacturers. Sumitomo Chemical Co. used this process as well into the early 1980s and had licensed their knowhow to Hindustani Organic Chemicals, Ltd. of India which started up a plant on this basis with a capacity for MAP of 1.5 mill. lb /yr in 1970.The output of the Indian plant was said to be devoted to making sodium p-aminosalycilate (PAS), a tuberculostatic agent.
Uses	3-Aminophenol is an aromatic compound used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery.
Definition	ChEBI: An aminophenol that is one of three amino derivatives of phenol which has the single amino substituent located meta to the phenolic -OH group.
Application	3-Aminophenol has been used in the synthesis of disulfonated bis[4-(3-aminophenoxy)phenyl]sulfone (S-BAPS). It can be used to synthesize: Methyl 2-oxo-7-[(triphenylphosphoranylidene)amino]-2H-chromene-4-carboxylate by reacting with dimethyl acetylenedicarboxylate (DMAD) in the presence of triphenylphosphine. 3-Amino-2-cyclohexen-1-one via palladium-catalyzed hydrogenation.
Synthesis Reference(s)	Tetrahedron Letters, 25, p. 1479, 1984 DOI: 10.1016/S0040-4039(01)80191-X
General Description	White crystals or off-white flakes.
Air & Water Reactions	3-Aminophenol may be sensitive to prolonged exposure to air and light. Slightly soluble in water.
Reactivity Profile	3-Aminophenol may react with strong oxidizers and mineral acids or bases.
Hazard	Toxic by ingestion.
Fire Hazard	Flash point data for 3-Aminophenol are not available. 3-Aminophenol is probably combustible.
Flammability and Explosibility	Non flammable
Safety Profile	Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx,.
Synthesis	3-Amino-2-cyclohexene-1-one (1.5 mol, 166.7 g), potassium acetate (6 mmol, 0.6 g), and 5% palladium on carbon (4.7 g, 65.5% water) were added to N, N-dimethylacetamide (475 g) solvent in one liter creased round bottom flask equipped with a nitrogen purge, thermometer, condenser, distillation head, overhead stirrer, and heating mantle. The solution was then heated to reflux for two hours at 173° C. with a continuous nitrogen purge. The palladium catalyst was filtered from the solution. Gas chromatography analysis indicated 130.9 g 3-aminophenol (1.2 mole, 80% yield based on 3-amino-2-cyclohexene-1-one).
Potential Exposure	Workers may be exposed to oAminophenol during its use as a chemical intermediate; in the manufacture of azo and sulfur dyes; and in the photographic industry. There is potential for consumer exposure to o-Aminophenol because of its use in dyeing hair, fur, and leather. The compound is a constituent of 75 registered cosmetic products suggesting the potential for widespread consumer exposure. p-Aminophenol is used mainly as a dye, dye intermediate and as a photographic developer; and in small quantities in analgesic drug preparation. Consumer exposure to p-aminophenol may occur from use as a hairdye or as a component in cosmetic preparations. mAminophenol is used mainly as a dye intermediate
Shipping	UN2512 Aminophenols (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Purification Methods	Crystallise it from hot water or toluene. [Beilstein 13 IV 952.]
Incompatibilities	These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as alkali metals, hydrides, nitrides, and sulfides. Flammable gas (H2) may be generated, and the heat of the reaction may cause the gas to ignite and explode. Heat may be generated by the acidbase reaction with bases; such heating may initiate polymerization of the organic compound. Reacts with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock.
Toxics Screening Level	The Initial Threshold Screening Level (ITSL) is 390 μg/m3 annual average.
Waste Disposal	Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

3-Aminophenol Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Sulfuric acid-->Potassium hydroxide-->FUMING SULFURIC ACID-->Sodium sulfite-->Water-->Nitrobenzene-->Metanilic acid-->Benzenesulfonic acid sodium salt-->METANILIC ACID SODIUM SALT

Preparation Products

Resorcinol-->10-(2-Benzothiazolyl)-2,3,6,7-tetrahydro-1,1,7,7-tetramethyl-1H,5H,11H-(1)benzopyropyrano(6,7-8-I,j)quinolizin-11-one-->4-Aminosalicylic acid-->GLY-7-AMINO-4-METHYLCOUMARIN-->ERYTHROSIN B-->Rhodamine 123-->7-Hydroxyquinoline-->3-Bromophenol-->Coumarin 314T-->Coumarin 120-->Nedocromil-->3-Ethoxyaniline-->Phenmedipham-->9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine-->RHODAMINE 110-->Mepronil-->Direct Black 168-->ETHYL (3-HYDROXYPHENYL)CARBAMATE-->Coumarin 151-->3-ISOPROPOXYANILINE-->fluorescent whitening agent SWN-->3-dimethylaminophenyl dimethylcarbamate-->3-Dimethylaminophenol-->Sodium 4-aminosalicylate

Shop Semaglutide 910463-68-2C187H291N45O59-Detailed Image 3

Basic Info

Product Name:

3-Aminophenol

Other Name:

Phenol,3-amino-;Phenol,m-amino-;3-Aminophenol;C.I. 76545;m-Aminophenol;C.I. Oxidation Base 7;Fouramine EG;Fourrine 65;Fourrine EG;Furro EG;Futramine EG;Nako TEG;Pelagol EG;Renal EG;Tertral EG;Ursol EG;Zoba EG;m-Hydroxyaniline;1-Amino-3-hydroxybenzene;m-Hydroxyphenylamine;3-Hydroxyaniline;m-Hydroxyaminobenzene;3-Hydroxybenzenamine;m-Hydroxyaniline;Rodol EG;(3-Hydroxyphenyl)amine;NSC 1546

CAS No.:

591-27-5

Molecular Formula:

C6H7NO

InChIKeys:

InChIKey=CWLKGDAVCFYWJK-UHFFFAOYSA-N

Molecular Weight:

109.13

Exact Mass:

109.13

BRN:

636059

EC Number:

209-711-2

UNII:

L3WTS6QT82

NSC Number:

1546

UN Number:

2512

DSSTox ID:

DTXSID3024497

Color/Form:

White prisms from toluene or water|White crystals

HScode:

29222900

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

46.2

XLogP3:

0.21 at pH 5.6

Appearance:

White to pinkish or light gray Crystalline Powder

Density:

1.195 g/cm³

Melting Point:

122-123 °C

Boiling Point:

164 °C @ Press: 11 Torr

Flash Point:

155 °C

Refractive Index:

1.637

Water Solubility:

H2O: 35 g/L (20 ºC)

Storage Conditions:

2-8°C

Vapor Pressure:

1.86X10-3 mm Hg at 25 deg C (est)

Toxicity:

Oral-rat LD50: 924 mg/kg; Oral-Mouse LD50: 401 mg/kg

Flammability characteristics:

Open flames are flammable; heated to decompose toxic nitrogen oxides and chloride gases

Henrys Law Constant:

Henry's Law constant = 2.7X10-10 atm-cu m/mole at 25 °C (est)

Dissociation Constants:

pK1 = 4.37 at 20 °C; pK2 = 9.815 at 20 °C (conjugate acid)

Experimental Properties:

Heat of formation = -194.1 kJ/mol|Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molecule-sec at 25 °C (est)

Air and Water Reactions:

This compound may be sensitive to prolonged exposure to air and light. Slightly soluble in water.

Reactive Group:

Phenols and Cresols

Reactivity Profile:

M-AMINOPHENOL may react with strong oxidizers and mineral acids or bases. (NTP, 1992)

See More 3-Aminophenol Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H332 Harmful if inhaled H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store in tightly closed containers in a cool, well-ventilated area. Aminophenols must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine), since violent reactions occur. Aminophenols

See More 3-Aminophenol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

6 Inquiries

Country	Product	Purchase Quantity	Date Posted
Turkey	M-Aminophenol (3-Aminophenol)	100	May 11, 2026
India	3-Aminophenol	500 KG	Sep 6, 2025
Turkey	M-AMINOPHENOL	1 KG	Dec 24, 2024
India	3-Amino phenol	300 KG	Dec 16, 2025
India	Meta Amino phenol	500.00 KG	Sep 4, 2023
Vietnam	Hair dye intermediates	1000 KG	Dec 4, 2024

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