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Home > Encyclopedia > Glutaraldehyde

Glutaraldehyde

pharmaceutical raw materials
Glutaraldehyde structure

Glutaraldehyde 

structure
  • CAS No:

    111-30-8

  • Formula:

    C5H8O2

  • Chemical Name:

    Glutaraldehyde

  • Synonyms:

    Pentanedial;Glutaraldehyde;Glutardialdehyde;Glutaric dialdehyde;Glutaric acid dialdehyde;Glutaral;1,5-Pentanedial;Sonacide;Hospex;Aldesan;Glutarex 28;Relugan GT;Relugan GT 50;Sporicidin;Cidex 7;Ucarcide 250;Relugan GTW;Glutaclean;Sterihyde;Bactron K 31;Sterihyde L;Cidex-Dialyzer;Tret-O-Lite XC 102;Biomate 743;Glutohyde;Banicide;Panavirocide;Floperm 665X1;Diglutaric aldehyde;Cleancide 275;Cidex;Cidexplus;Wavicide 01;Piror 850;Surcide G 50;Glu-Cid;Sellatan CF-N;NSC 13392;Aqucar 550;Venno-FF super;Sterisol S;Kcide 850;Permachem OB 5;Biocide G 30;Metricide Plus;Maxicide Plus;5-Oxopentanal;Bioban Eth 1000;T 352;Eimaldehyde;KS 02;Formula H;Ukatan 24;Protectol GA 50;Odycide B 310;Ucarcide 50;Ucarcide 50 Antimicrobial;Ucarcide 250 Antimicrobial;GT 50;G 6257;NovaCide 1125;37245-61-7;79215-57-9;107950-89-0;1428979-54-7;1497435-71-8

  • Categories:

    Cosmetic Ingredient  >  Cosmetic Preservative

Description

Glutaraldehyde is a colorless liquid with a pungent odor, which readily changes to a glossy polymer. The Odor Threshold is 0.04 ppm (NY) and 0.2 ppm (NJ). It is miscible in water and organic solvents. Glutaraldehyde may be incompatible with strong oxidizers and strong bases. It should be noted that alkaline solutions containing glutaraldehyde may react with alcohol, ketones, amines, hydrazines, and proteins.

Glutaraldehyde Basic Attributes

100.11600

100.12

203-856-5

2912190090

Characteristics

34.14000

0.55450

Glutaraldehyde solution is a light yellow liquid. Mixes with water. (USCG, 1999)

0.72 g/cm3

-6 °C

101 °C

71ºC

1.373

Miscible

2-8ºC

0.583mmHg at 25°C

Relative vapour density (air = 1): 3.5

LD50 of 25% soln orally in rats: 2.38 ml/kg; by skin penetration in rabbits: 2.56 ml/kg (Smyth)

Noncombustible Liquid

Not explosive

Pungent odor

Mildly acidic (50% solution)

Safety Information

II

8

UN 2810

3

R22; R23; R34; R42/43

S26-S36/37/39-S45

MA2450000

T

Store only in original container. Well closed. Separated from food and feedstuffs, incompatible materials and amines. Separated from strong oxidizers and strong bases. Keep in a well-ventilated room. Keep in the dark.

Glutaral loses activity within 2 wk after prepn.

P261-P273-P280-P305 + P351 + P338-P310

H302 + H332-H314-H317-H334-H335-H400-H411

Glutaraldehyde Use and Manufacturing

1. Recommended for techniques demanding high purity.
2. Contains variable amounts of polymer.1
3. Cross-linking agent for gelatin,1,2 poly(vinyl alcohol),3 and polyheptapeptides.4
4. Glutaraldehyde is used to disinfect medical and dental equipment. Glutaraldehyde is also used for industrial water treatment and as a preservative.

Computed Properties

Molecular Weight:100.12
XLogP3:-0.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:100.052429494
Monoisotopic Mass:100.052429494
Topological Polar Surface Area:34.1
Heavy Atom Count:7
Complexity:51.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Downstream Products

Price Analysis

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Drug Function and Efficacy

Glutaraldehyde was originally used as a fixative for pathological specimens. It has the strongest effect when the pH value is 7.5-8.5. It can kill bacterial propagules and spores, fungi, and viruses. Its effect is 2-10 times that of formaldehyde. The mechanism of glutaraldehyde killing microorganisms is that the free aldehyde group combines with the amino group of the cell surface or internal protein or enzyme to cause a series of reactions, leading to the death of the microorganism.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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