Poly(I:C)
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Poly(I:C)
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CAS No:
24939-03-5
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Formula:
(C10H13N4O8P)x.(C9H14N3O8P)x
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Chemical Name:
Poly(I:C)
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Synonyms:
5′-Inosinic acid,homopolymer,complex with 5′-cytidylic acid homopolymer (1:1);5′-Inosinic acid,polymers,complex with 5′-cytidylic acid polymers (1:1);5′-Cytidylic acid,polymers,complex with 5′-inosinic acid polymers (1:1);5′-Cytidylic acid,homopolymer,complex with 5′-inosinic acid homopolymer (1:1);Poly(C).poly(I);Polyribocytidylic acid-polyriboinosinic acid complex;Poly(C:I);Polycytidylic-polyinosinic acid;Polyinosinic-polycytidylic acid complex;Polyinosinic-polycytidylic acid;Poly(rI:rC);Polyinosinic acid:polycytidylic acid;Polyinosinate:polycytidylate;Polyinosinic acid:polycytidylic acid complex;Poly(I).poly(C);Poly(rI).poly(rC);Poly(I:C);Poly(rI):poly(rC);Poly(cytidylic acid)-poly(inosinic acid);Poly(I).poly(C) complex;Poly(rI)-poly(rC);5′-Inosinic acid homopolymer-5′-cytidylic acid homopolymer complex (1:1);Polyinosinate-polycytidylate complex;NSC 120949;NSC 123233;NSC 128576;Polyinosine-polycytidylic acid;Poly(I)-poly(C);Poly I:C;104888-55-3;53539-97-2;61216-07-7
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CAS No:
Description
ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Poly(I:C) Use and Manufacturing
Preparation of 5'-nucleoside diphosphate pyridinium salt with 5'-nucleotide as raw material 5'-nucleotide (5'-inosinic acid or 5'-cytidine acid) [morpholine, bicyclohexylcarbodiimide Amine]→[Ethanol, 83℃]5'-nucleotide morpholine salt [tri-n-butylamine phosphate, anhydrous pyridine]→5'-nucleoside diphosphate pyridinium salt (DIP pyridine salt or CDP pyridine salt) fixation Preparation of phosphopolynucleotide phosphorylase enzyme preparation E. coli 1.683 cell → broken cell extraction → nucleic acid removal by streptotoxin precipitation → ammonium sulfate salting out → DEAE-cellulose chromatography → collection of 0.35mol/L sodium chloride for elution Preparation of the part of the solid phase carrier with the highest enzyme activity in the liquid. Agar powder is melted [toluene, carbon tetrachloride, Span-80] → After stirring and cooling, it is cross-linked with epichlorohydrin to form beads [p-β-sulfate ethyl ester] Sulfonyl aniline]→[etherification]→[sodium nitrite, hydrochloric acid]→solid phase carrier Add the separated and purified enzyme solution dropwise to the solid phase carrier in an ice bath to obtain the covalently bound immobilized polynucleotide phosphorylation Enzyme. The preparation of polyinosinic acid reduces the substrate IDP pyridine salt into sodium salt, and CDP pyridine salt into lithium salt. Enzymatic reaction, (the number of μmol/L per ml reaction solution) IDP or CDP15, Tris150, magnesium chloride 6, EDTA1, polymerase 5U, pH 9.0, 37°C, 3-4h, adjust pH 1.5-2.0 with hydrochloric acid to polymerize Creatine or polycytidylic acid is precipitated, centrifuged, and then dissolved in a phosphate buffer, and equimolar polycreatine and polycytidine are mixed to obtain polyinosine.
It has the role of immune adjuvant, which can stimulate the reticuloendothelial system, enhance the phagocytic function of phagocytes, enhance the formation of antibodies, and stimulate allograft reactions and delayed allergic reactions. It has broad-spectrum antiviral and antitumor effects. It is mainly used clinically to prevent or treat viral infections, to treat herpes zoster, herpes keratitis, and viral hepatitis. Adjuvant treatment of tumors. Adverse reactions mainly include transient hypothermia, and individual cases have high fever above 38℃, which usually subsides within 1-2 days. If the fever does not disappear within 2 days, the drug should be stopped immediately. See also fatigue, dry mouth, dizziness, nausea, etc.
Drug Function and Efficacy
No specific pharmacological effects mentioned
Registered Holders
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Wuzhi Weierkang Biochemical Pharmaceutical Co., Ltd.
Active
China
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Kaiping Genuine Biochemical Pharmaceutical Co., Ltd.
Active
China
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