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5-Fluorouracil

5-Fluorouracil structure

CAS No:
51-21-8
Formula:
C4H3FN2O2
Chemical Name:
5-Fluorouracil
Synonyms:
2,4(1H,3H)-Pyrimidinedione,5-fluoro-;Uracil,5-fluoro-;5-Fluoro-2,4(1H,3H)-pyrimidinedione;NSC 19893;Ro 2-9757;5-Fluorouracil;Fluorouracil;2,4-Dioxo-5-fluoropyrimidine;Efudex;5-FU;Fluracil;Fluril;Fluoroplex;5-Fluoro-2,4-pyrimidinedione;Fluoroblastin;Phtoruracil;Phthoruracil;Fluracilum;Efurix;Queroplex;Arumel;Kecimeton;Adrucil;Efudix;Carzonal;Ulup;Ftoruracil;U 8953;Timazin;FU;Fluri;5-Fluoracyl;Carac;2,4-Dihydroxy-5-fluoropyrimidine;Fluracedyl;5-Fluoropyrimidine-2,4-diol;Flurablastin;DBL;5-Fluoro-1H-pyrimidine-2,4-dione;Fluorouracile Accord;5-Oncouracil;Sigma 03738;5-Fluoro-2,4-dihydroxypyrimidine;1004-03-1;4921-97-5;79108-01-3
Categories:
Biochemical Engineering > Nucleoside Drugs

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Description

White or almost white, crystalline powder Fluorouracil is a white crystalline solid. Practically odorless.

5-Fluorouracil Basic Attributes

Molecular Weight：

130.08

Exact Mass：

130.08

BRN：

127172

EC Number：

200-085-6

HScode：

29335995

Characteristics

PSA：

58.2

XLogP3：

-0.8

Appearance：

white powder

Density：

1.4593 (estimate)

Melting Point：

282 °C (decomp)

Boiling Point：

190-200°C/0.1mmHg

Flash Point：

196.5ºC

Refractive Index：

1.542

Water Solubility：

H2O: 12.2 g/L 20 ºC

Storage Conditions：

Storeat0-5

Vapor Pressure：

2.68X10-6 mm Hg at 25 deg C (est)

Toxicity：

LD50 orally in Rabbit: 230 mg/kg

Odor：

PRACTICALLY ODORLESS

PKA：

8.02None

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

22-20/21/22-52-25

safety instructions：

36-36/37-36/37/39-22-45-26

RTECS Number：

YR0350000

Marks：

Xn,T,C,Xi

Hazard note：

Irritant/Highly Toxic

Stability/Shelf Life：

Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.

Precautionary statement(s)：

P201, P202, P260, P264, P270, P281, P301+P310, P308+P313, P314, P321, P330, P405, P501

Hazard Statements：

H301

5-Fluorouracil Use and Manufacturing

5-Fluoro Uracil is an active metabolite of Doxifluridine(D556750).

Computed Properties

Molecular Weight:130.08
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:130.01785550
Monoisotopic Mass:130.01785550
Topological Polar Surface Area:58.2
Heavy Atom Count:9
Complexity:199
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is first converted into 5-fluoro-2-deoxyuridine nucleotide in the body, which inhibits thymine nucleotide synthetase, blocking the conversion of deoxyuridine nucleotide into deoxythymine nucleotide, thereby inhibiting DNA biosynthesis. In addition, by preventing uracil and orotic acid from incorporating into RNA, the effect of inhibiting RNA synthesis is achieved. This product is a cell cycle-specific drug that mainly inhibits S-phase cells.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fluorouracil Injection
Ingredients	The chemical name of this product is: 5-fluoro-2,4(1H,3H)-pyrimidinedione.
Indication	Not yet clear.
Specifications	10ml:0.25g
Manufacturer	Heilongjiang Fuhe Pharmaceutical Group Co., Ltd.

Compound fluorouracil oral solution
Ingredients	The product is an oral solution mainly made of fluorouracil and ginseng polysaccharide. The fluorouracil (C4H3FN2O2) content should be 90.0% to 110.0% of the labeled amount. The prescription is 4g of fluorouracil, 8g of ginseng polysaccharide, 20g of soybean lecithin, and an appropriate amount of water, a total of 1000ml.
Specifications	0.4% (fluorouracil)
Manufacturer	Heilongjiang Ruige Pharmaceutical Co., Ltd.

Compound fluorouracil oral solution
Ingredients	It is an oral solution mainly made of fluorouracil and ginseng polysaccharide. The fluorouracil (C4H3FN2O2) content should be 90.0% to 110.0% of the labeled amount. The prescription is 4g of fluorouracil, 8g of ginseng polysaccharide, 20g of soybean lecithin, and an appropriate amount of water, a total of 1000ml.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.4% (fluorouracil)

See More Related Drugs

Registered Holders

Nantong Jinghua Pharmaceutical Co Ltd

United States
Active
IMCD Switzerland AG

Switzerland
Active
TAPI NL B.V.

France
Active

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Guide of 5-Fluorouracil

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

5-Fluorouracil

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