Systemic infection caused by pathogenic bacteria invading the blood circulation and growing and multiplying therein, producing toxins, is easy to occur when the body's resistance is reduced. Clinically, it mainly manifests as chills, high fever, symptoms of toxemia, rash, joint pain, hepatosplenomegaly, septic shock, migratory lesions, etc. It is divided into Gram-positive coccal sepsis, Gram-negative bacillary sepsis and septic sepsis. Most of them have an acute course, severe condition and poor prognosis. It is now further believed that sepsis is a series of chain reaction processes caused by the activation and release of inflammatory mesons after pathogenic bacteria and their toxins and metabolites enter the bloodstream. This process can clinically lead to dysfunction and failure of multiple organs in the body. That is, not only the existence of pathogenic bacteria in the body is seen, but also the body's immune response and results are valued. It is now known that inflammatory mediators include complement components, arachidonic acid metabolites, tumor factor (TNF), interleukin (IL-s), interferon (IF-a), platelet activating factor (PAF), macrophage proinflammatory cytokine (MPIC), protease, thromboxane and oxygen free radicals. Antibiotic treatment is the main treatment, supplemented by other treatment methods. Preventive measures are to avoid damage to the skin and mucous membranes and prevent bacterial infection.