Glucocorticoids have been widely used in clinical practice as the first-line treatment for asthma. Most asthma patients can significantly improve clinical symptoms and pathophysiological changes in a short period of time by taking oral high-dose prednisone. For children and adults with initial diagnosis of asthma, both high-dose and low-dose inhaled hormones can relieve symptoms and improve lung function. However, not all asthma patients show efficacy in hormone treatment. Some patients do not respond well to long-term or high-dose hormones. This is hormone-resistant asthma (glucocoticoid resistant asthma, GRA). In addition to clarifying the asthma diagnostic rules and applying hormones in sufficient amounts, the diagnosis of hormone-resistant asthma also requires the exclusion of factors that cause hormone resistance and strict differential diagnosis. Bronchodilators are the first-line drugs for the treatment of hormone-resistant asthma. Correspondingly, asthma that shows good efficacy in hormones is hormone-sensitive asthma (glucocoticoid sensitiVe asthma, GSA).