Pachyermoperiostosis is also known as hypertrophic skin periosteal bone hyperplasia and Touraine-Solente-Gole syndrome. The primary form may be autosomal dominant, and the secondary form is also called hyperproliferative osteoarthropathy. It is often secondary to various chronic and malignant tumor diseases, and the pathogenesis is still unclear. Primary pachyermoperiostosis is mainly seen in men, which may be an autosomal dominant genetic disease with different penetrances. Such cases have been reported in China. Secondary pachyermoperiostosis may also be a genetic disease, but it is often stimulated by severe liver disease, bronchial lung cancer or epithelial adenocarcinoma, bronchiectasis, lung abscess, or gastric cancer, esophageal cancer, thymic cancer, etc.