Hepatolenticular degeneration is an autosomal recessive hereditary disease caused by a decrease in the level of ceruloplasmin (a copper-binding enzyme) in plasma. It is also called Wilson's disease because it was first reported by Wilson in 1912. This disease is caused by acetone metabolism disorders in the body, leading to lesions in liver, brain and other tissues. The clinical features are extrapyramidal symptoms, liver damage and characteristic corneal pigment rings, and are often accompanied by varying degrees of mental disorders. The age of onset ranges from adolescence to middle age, and about half of the patients are between 20 and 30 years old. Because of the frequent occurrence of mental symptoms, it is easy to be misdiagnosed as a primary mental disorder. Its condition continues to progress, and most of them have a poor prognosis.