Insulin resistance is one of the hot issues that everyone is concerned about. As early as the 1960s, people observed that impaired glucose tolerance (IGT), diabetes, obesity, lipid metabolism disorders and hypertension often appeared simultaneously in the same individual. At that time, some people called it prosperity syndrome, but for a long time people did not understand why the various components of the syndrome appeared successively or simultaneously in the same individual or the same family, so it was also called X syndrome. It was not until Reaven first proposed the insulin resistance syndrome in 1988 that people linked the above-mentioned manifestations with insulin resistance and believed that their common pathological basis for the onset of the disease was insulin resistance. The definition of insulin resistance: the body's reduced responsiveness or sensitivity to the physiological effects of insulin. Insulin resistance in a narrow sense refers to the reduced responsiveness of tissue cells to insulin-mediated glucose utilization. The main sites of insulin resistance are the liver, muscle and adipose tissue.