Idiopathic hypogonadotropic hypogonadism
Hypogonadotropic hypogonadism (HH) includes a large group of diseases. Congenital GnRH neuron defects, pituitary gonadotropin deficiency or molecular structural abnormalities, chronic systemic diseases, mental stress, severe weight loss or long-term strenuous exercise can all cause gonadotropin deficiency. In addition, gonadotropin deficiency is also a component of some congenital syndromes (such as Prader-Willi syndrome, Laurence-Moon-Biedl syndrome, etc.). The degree of gonadotropin deficiency is also heterogeneous. One extreme is the complete absence of pubertal sexual maturity, the other extreme is delayed puberty, and in between are different degrees of excessive types.