Lambert-Eaton syndrome, also known as myasthenia-like syndrome, is a special type of myasthenia and autoimmune disease involving cholinergic synapses. First described by Lambert, Eaton and Rooke (1956), the disease is characterized by weakness and fatigue of the proximal limb muscle groups. After a short and forceful contraction of the affected muscle, the muscle strength is enhanced, and after continuous contraction, there is pathological fatigue. Lambert-Eaton syndrome is a transmission disorder at the neuromuscular junction. It is caused by the loss of presynaptic calcium channels by anti-P/Q-type voltage-gated calcium ion channel (P/Q-type VGCC) antibodies, which reduces the number of minimum release units of acetylcholine released at the presynaptic membrane and causes myasthenia.