Capecitabine structure
Capecitabine
Colourless solidCapecitabine is a new oral fluoropyrimidine carbamate for patients with
advanced neoplastic disease, approved as Xeloda for the treatment of refractory
metastatic breast cancer after failure on Paclitaxel and an anthracycline-based
chemotherapy regimen ; it is a prodrug of doxifluridine (5-fluorouracil ; 5-FU)
activated by a cascade of 3 enzymes concentrated in human liver and cancer
tissue, resulting in the selective release of 5-FU at the tumor site and offering a
prolo
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