Beijing Sihuan Kebao Pharmaceutical Co., Ltd.

In the carbon tetrachloride model, it can reduce the serum transaminase of animals and the hydroxyproline content in the liver, alleviate the degree of liver lesions, and reduce the level of DHBV-DNA in the serum of ducks infected with hepatitis B virus (HBV); in vitro, it can inhibit the proliferation of mouse skin fibroblasts (NIH/3T3 cells) and the synthesis of extracellular matrix, inhibit the proliferation and synthesis of extracellular matrix of rat hepatic stellate cells and promote their apoptosis; in the rat liver fibrosis model induced by carbon tetrachloride, dimethylnitrosamine and galactosamine, after oral prevention and treatment with matrine, the serum transaminase, extracellular matrix (hyaluronic acid, laminin, type III collagen and type IV collagen) content of animals, as well as the degeneration, necrosis, inflammatory activity and fibrosis degree of liver cells in liver tissue were significantly improved.

By acting on the smooth muscle of the coronary and peripheral blood vessels and the atrioventricular node, inhibiting the influx of Ca2 into the cells, it shows the effect of vasodilation and prolonging the conduction time of the atrioventricular node, thus being effective for hypertension, arrhythmia, and angina pectoris. 1. Effect on blood pressure: It can reduce hypertension under anesthesia or without anesthesia, reduce peripheral vascular resistance and myocardial oxygen consumption while lowering blood pressure, increase cardiac output, and reduce blood pressure and sodium diuresis without reducing the blood flow to the brain, coronary arteries, and kidneys. 2. Effect on arrhythmia: Prolong the conduction time, effective refractory period, and functional refractory period of the atrioventricular node, show effects on supraventricular tachyarrhythmia, and inhibit supraventricular tachyarrhythmia caused by atrial electrical stimulation. 3. Effect on myocardial ischemia: Improve the balance of myocardial oxygen supply and demand (dilate the main coronary artery and side branches, increase blood flow to the ischemic part of the myocardium, and inhibit coronary artery spasm), and myocardial protection (inhibit excessive influx of Ca2 into cells during myocardial ischemia, maintain cardiac function and myocardial energy metabolism, and reduce infarct focus).

Extract from the above information

No specific pharmacological effects mentioned