Beijing Institute of Biological Products Co., Ltd. | Pharmaceutical Manufacturer Profile & Drug Portfolio Page 3

Rubella vaccine, live attenuated (human diploid cells)

This product is made by inoculating human diploid cells with an attenuated strain of rubella virus, culturing and harvesting the virus liquid, and then adding a suitable stabilizer and freeze-drying it.

Name	Description	Content	CAS NO.	Registered Holders
Attenuated Rubella virus	Attenuated rubella virus can stimulate antibody-forming cells in the human body to produce antibodies that have a neutralizing effect on rubella virus and is used to prevent rubella virus infection. More Attenuated rubella virus can stimulate antibody-forming cells in the human body to produce antibodies that have a neutralizing effect on rubella virus and is used to prevent rubella virus infection.			0

Buffered saline

The main ingredients of this product and its chemical name: Sodium chloride

Name	Description	Content	CAS NO.	Registered Holders
Sodium chloride	Sodium chloride is an electrolyte supplement. Sodium and chloride are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the amount of plasma sodium plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. Sodium and chloride ions in the human body are mainly regulated by the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure. More Sodium chloride is an electrolyte supplement. Sodium and chloride are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the amount of plasma sodium plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. Sodium and chloride ions in the human body are mainly regulated by the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure.		7647-14-5	42

Measles-rubella combined live attenuated vaccine

This product is made by inoculating primary chicken embryo cells with attenuated measles virus strain and human diploid cells with attenuated rubella virus strain, culturing and harvesting the virus liquid, mixing and preparing in proportion, adding a suitable stabilizer and freeze-drying. It is a loose body of cheese color, and after reconstitution, it is a clear orange-red liquid. Active ingredients: live attenuated measles and rubella viruses. Excipients: human serum albumin, gelatin and sucrose. Vaccine diluent: sterile water for injection.

Name	Description	Content	CAS NO.	Registered Holders
Measles virus, live attenuated	Vaccination stimulates the body to produce an immune response against measles virus More Vaccination stimulates the body to produce an immune response against measles virus			0
Rubella virus, live attenuated	Vaccination stimulates the body to produce an immune response against rubella virus More Vaccination stimulates the body to produce an immune response against rubella virus			0

MMR combined live attenuated vaccine

Measles, mumps, and rubella triple attenuated live vaccine. This vaccine is a live attenuated vaccine used for immunization prevention, including attenuated measles strains, mumps virus strains, and attenuated rubella strains. In addition to the above ingredients, this drug also contains about 25ug of neomycin, a small amount of sorbitol and hydrolyzed gelatin as stabilizers

Name	Description	Content	CAS NO.	Registered Holders
Measles attenuated strain	A single vaccination can induce 95% of measles HI antibodies More A single vaccination can induce 95% of measles HI antibodies			0
Mumps virus strains	A single vaccination can induce 96% of mumps neutralizing antibodies More A single vaccination can induce 96% of mumps neutralizing antibodies			0
Rubella attenuated strain	A single vaccination can induce 99% of Rubella HI antibodies More A single vaccination can induce 99% of Rubella HI antibodies			0
Neomycin	Clinical studies in 279 children aged 11 months to 7 years who were seronegative for all three viruses showed that M-M-RII was highly immunogenic and generally well tolerated. In these studies, a single vaccination in susceptible individuals elicited 95% production of measles hemagglutination inhibition (HI) antibodies, 96% production of mumps neutralizing antibodies, and 99% production of rubella HI antibodies. However, 1-5% of recipients failed to seroconvert after the initial vaccination. More Clinical studies in 279 children aged 11 months to 7 years who were seronegative for all three viruses showed that M-M-RII was highly immunogenic and generally well tolerated. In these studies, a single vaccination in susceptible individuals elicited 95% production of measles hemagglutination inhibition (HI) antibodies, 96% production of mumps neutralizing antibodies, and 99% production of rubella HI antibodies. However, 1-5% of recipients failed to seroconvert after the initial vaccination.	25μg	1404-04-2	3

MMR combined live attenuated vaccine

Measles, mumps, and rubella triple attenuated live vaccine. This vaccine is a live attenuated vaccine used for immunization prevention, including attenuated measles strains, mumps virus strains, and attenuated rubella strains. In addition to the above ingredients, this drug also contains about 25ug of neomycin, a small amount of sorbitol and hydrolyzed gelatin as stabilizers

Name	Description	Content	CAS NO.	Registered Holders
Measles attenuated strain	A single vaccination can induce 95% of measles HI antibodies More A single vaccination can induce 95% of measles HI antibodies			0
Mumps virus strains	A single vaccination can induce 96% of mumps neutralizing antibodies More A single vaccination can induce 96% of mumps neutralizing antibodies			0
Rubella attenuated strain	A single vaccination can induce 99% of Rubella HI antibodies More A single vaccination can induce 99% of Rubella HI antibodies			0
Neomycin	Clinical studies in 279 children aged 11 months to 7 years who were seronegative for all three viruses showed that M-M-RII was highly immunogenic and generally well tolerated. In these studies, a single vaccination in susceptible individuals elicited 95% production of measles hemagglutination inhibition (HI) antibodies, 96% production of mumps neutralizing antibodies, and 99% production of rubella HI antibodies. However, 1-5% of recipients failed to seroconvert after the initial vaccination. More Clinical studies in 279 children aged 11 months to 7 years who were seronegative for all three viruses showed that M-M-RII was highly immunogenic and generally well tolerated. In these studies, a single vaccination in susceptible individuals elicited 95% production of measles hemagglutination inhibition (HI) antibodies, 96% production of mumps neutralizing antibodies, and 99% production of rubella HI antibodies. However, 1-5% of recipients failed to seroconvert after the initial vaccination.	25μg	1404-04-2	3