Guangdong Huanan Pharmaceutical Group Co., Ltd.

It has strong anti-inflammatory and immunosuppressive effects. In terms of anti-inflammatory effects, it can antagonize and inhibit the release of inflammatory mediators, experimental inflammation and the degree of arthritis response. In terms of immunosuppressive effects, it can inhibit humoral immunity and cellular immune responses.

1. Anti-inflammatory effects: (1) Anti-allergic effects. Glycyrrhizin has anti-allergic effects such as inhibiting local allergic necrosis reactions in rabbits and inhibiting Schwartzman phenomenon. It enhances the inhibitory effect of corticosteroids on stress response and antagonizes the anti-granulation and thymic atrophy effects of hormones. It has no effect on the exudation of hormones. (2) Inhibitory effect on arachidonic acid metabolic enzymes. Glycyrrhizin selectively inhibits the phosphorylation of these enzymes and inhibits their activation. 2. Immunomodulatory effects: (1) Regulatory effect on T cell activation; (2) Inducing effect on gamma interferon; (3) Activating NK cells; (4) Promoting the differentiation of extrathymic T lymphocytes. 3. Inhibitory effect on experimental hepatocyte damage. In the primary cultured rat hepatocyte cell line in vitro, glycyrrhizin inhibited hepatocyte damage caused by carbon tetrachloride. 4. It can inhibit virus proliferation and inactivate viruses. It can prolong the survival days of mice in the MHV infection experiment. It can prevent the occurrence of acne in rabbits in the cowpox virus pox prevention experiment. In vitro experiments have been observed to inhibit the proliferation of herpes viruses and inactivate viruses.

1. Effect on water and electrolyte excretion: It can increase the excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphorus, etc.; mainly by inhibiting the active reabsorption of NaCl by the thick-walled segment of the renal tubular loop, reducing the osmotic pressure gradient difference of the medullary interstitial fluid, and reducing the renal tubular concentration function, thereby increasing the excretion of water, Na, and Cl. At the same time, it may also inhibit the reabsorption of Na and Cl by the proximal and distal tubules, and promote the secretion of K by the distal tubules. 2. Effect on hemodynamics: Furosemide can inhibit the activity of prostaglandin degrading enzymes, increase the content of prostaglandin E2, and has a vasodilatory effect; dilate renal blood vessels, reduce renal vascular resistance, and increase renal blood flow; it is of great significance in diuresis, and is helpful for the treatment of acute left heart failure and provides a theoretical basis for the treatment of adult respiratory distress syndrome.

Antipyretic, analgesic, antibacterial, anti-inflammatory, litholytic and choleretic, antispasmodic, sedative

It has multiple pharmacological effects such as antipyretic, analgesic, antibacterial, anti-inflammatory, litholytic and choleretic, antispasmodic, and sedative.