Teyi Pharmaceutical Group Co., Ltd.

It has a good antibacterial effect on human tuberculosis bacteria, and its bactericidal effect is strongest at pH 5-5.5. It is currently the best bactericidal drug for tuberculosis bacteria that grow slowly in phagocytes in an acidic environment. The antibacterial concentration in the body is 12.5ug/ml, and 50ug/ml can kill tuberculosis bacteria. The concentration that inhibits tuberculosis bacteria inside cells is 10 times lower than that outside cells, and it has almost no antibacterial effect in neutral and alkaline environments. The mechanism of action may be related to pyrazinoic acid. After pyrazinamide penetrates into phagocytes and enters the tuberculosis bacteria, the amidase in the bacteria removes the amide group and converts it into pyrazinoic acid to exert an antibacterial effect. In addition, because pyrazinamide is similar to nicotinamide in chemical structure, it interferes with dehydrogenase by replacing nicotinamide, prevents dehydrogenation, and hinders the use of oxygen by tuberculosis bacteria, which affects the normal metabolism of bacteria and causes death.

It has a good antibacterial effect on human tuberculosis bacteria, and its bactericidal effect is strongest at pH 5-5.5. It is currently the best bactericidal drug for tuberculosis bacteria that grow slowly in phagocytes in an acidic environment. The antibacterial concentration in vivo is 12.5 mu; g/ml, and 50 mu; g/ml can kill tuberculosis bacteria. The concentration that inhibits tuberculosis bacteria inside cells is 10 times lower than that outside cells, and it has almost no antibacterial effect in neutral and alkaline environments. The mechanism of action may be related to pyrazinoic acid. After pyrazinamide penetrates into phagocytes and enters the tuberculosis bacteria, the amidase in the bacteria removes the amide group and converts it into pyrazinoic acid to exert an antibacterial effect. In addition, because pyrazinamide is similar to nicotinamide in chemical structure, it interferes with dehydrogenase by replacing nicotinamide, prevents dehydrogenation, and hinders the use of oxygen by tuberculosis bacteria, which affects the normal metabolism of bacteria and causes death.

Reserpine is an adrenergic neuron blocking antihypertensive drug. It achieves antihypertensive, heart rate slowing and central nervous system inhibition effects by depleting adrenaline in peripheral sympathetic nerve endings, catecholamines and 5-hydroxytryptamine in the heart, brain and other tissues. The antihypertensive effect is mainly achieved by reducing cardiac output and peripheral resistance, and partially inhibiting cardiovascular reflexes. The effect of slowing the heart rate is not obvious in people with normal heart rate, but it is obvious in people with sinus tachycardia. Reserpine acts on the hypothalamus to produce a sedative effect, but does not cause drowsiness or anesthetic effects, does not change the electroencephalogram during sleep, and can relieve anxiety, tension and headaches in hypertensive patients.

Long-term and large-area use can absorb into the body and produce the same adverse reactions as oral sulfonamides, such as blood count changes, liver damage, kidney damage, etc.

If used over a long period of time and over a large area, sulfonamides can be absorbed into the body and may produce the same adverse reactions as oral sulfonamides, including changes in blood counts, liver damage, and kidney damage.