Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.

After 0.5-1g of intramuscular injection in adults, the content in cerebrospinal fluid is less than 0.00002% 2 hours later. After intravenous injection, about 60% is bound to plasma albumin. This product does not participate in metabolism in the body, nor is it firmly bound to tissues. It is mainly excreted from urine through the kidneys, and a small part is excreted from bile through the liver, and is basically excreted from the body within 24 hours.

It is a natural substance in the body that is essential for mammalian energy metabolism. Its main function is to promote lipid metabolism. In ischemia and hypoxia, it can reduce the accumulation of acyl-CoA, increase the level of free carnitine, maintain the activity of adenine nucleotide translocase, and promote the smooth progress of oxidative phosphorylation. As the main energy source for muscle cells, especially myocardial cells, it can also increase the activity of NADH cell C pigment reductase and cytochrome oxidase, accelerate ATP production, and participate in drug detoxification. At the same time, it provides energy through fatty acid oxidation, regulates the ratio of bound coenzyme A to free coenzyme A, generates energy from ketones, pyruvate, and amino acids, removes the toxicity of excessive coenzyme A, and regulates the ammonia concentration in the blood.

The anti-tumor target is microtubules, mainly inhibiting the polymerization of tubulin and affecting the formation of spindle microtubules. It stops mitosis at metaphase. It can also interfere with protein metabolism and inhibit the activity of RNA polymerase, and inhibit the synthesis of cell membrane lipids and the transport of amino acids on the cell membrane. The inhibitory effect on transplanted tumors is greater than that of vinca alkaloids and has a wide anti-tumor spectrum. In addition to being effective against tumor strains sensitive to vinca alkaloids, it also has effects on mouse Ridgeway osteosarcoma, Mecca lymphosarcoma, X-5563 myeloma, etc. There is no cross-resistance between vincristine, vinblastine and vindesine, and vincristine has the strongest neurotoxicity among the three.