In acute toxicity experiments, the LD50 in mice and rats was greater than 4000 mg/Kg. In subacute toxicity experiments, Wistar male and female rats were given 40 mg, 200 mg and 1000 mg/Kg per day for 5 weeks, and male and female rabbits were given 6 mg, 60 mg and 600 mg/Kg per day for 23 consecutive days. There were no special changes in the blood, urine and morphological observations of the test animals. In chronic toxicity experiments, Wistar male and female rats were given 6 mg, 60 mg and 600 mg/Kg per day for 26 consecutive weeks. There were no special changes in the general state, blood and urine examinations, and morphological observations of the test animals.

Macrolide antibiotics have inhibitory effects on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus, and Pneumococcus, as well as some Gram-negative bacteria such as Haemophilus influenzae, Bordetella pertussis, Neisseria gonorrhoeae, Legionella pneumophila, and some anaerobic bacteria such as Bacteroides fragilis, Streptococcus peptostreptococcus, and Propionibacterium acnes. In addition, they also have inhibitory effects on mycoplasmas. In vivo, the antibacterial activity against some bacteria such as Staphylococcus aureus, Streptococcus, and Haemophilus influenzae is stronger than that of erythromycin. The antibacterial effect is produced by hindering the association of the 50S subunit of the nucleoprotein and inhibiting protein synthesis.

Kills bacteria by inhibiting cell wall synthesis. It is highly resistant to beta-lactamase produced by bacteria and is highly sensitive to Gram-positive, Gram-negative aerobic and anaerobic pathogens.