SINO-AMERICAN Shanghai Squibb Pharmaceuticals Ltd. | Pharmaceutical Manufacturer Profile & Drug Portfolio

Entecavir

Name	Description	Content	CAS NO.	Registered Holders
Entecavir	This product is a guanine nucleoside analog that has an inhibitory effect on hepatitis B virus (HBV) polymerase. It can be converted into an active triphosphate through phosphorylation, and the half-life of the triphosphate in the cell is 15 hours. By competing with the natural substrate of HBV polymerase, deoxyguanosine triphosphate, entecavir triphosphate can inhibit all three activities of viral polymerase (reverse transcriptase): (1) HBV polymerase initiation; (2) formation of pregenomic mRNA reverse transcription negative strand; (3) synthesis of HBV DNA positive strand. The inhibition constant (Ki) of entecavir triphosphate on HBV DNA polymerase is 0.0012μM. Entecavir triphosphate has a weak inhibitory effect on cellular α, β, δ DNA polymerase and mitochondrial γ DNA polymerase, with Ki values ranging from 18 to 160μM. More This product is a guanine nucleoside analog that has an inhibitory effect on hepatitis B virus (HBV) polymerase. It can be converted into an active triphosphate through phosphorylation, and the half-life of the triphosphate in the cell is 15 hours. By competing with the natural substrate of HBV polymerase, deoxyguanosine triphosphate, entecavir triphosphate can inhibit all three activities of viral polymerase (reverse transcriptase): (1) HBV polymerase initiation; (2) formation of pregenomic mRNA reverse transcription negative strand; (3) synthesis of HBV DNA positive strand. The inhibition constant (Ki) of entecavir triphosphate on HBV DNA polymerase is 0.0012μM. Entecavir triphosphate has a weak inhibitory effect on cellular α, β, δ DNA polymerase and mitochondrial γ DNA polymerase, with Ki values ranging from 18 to 160μM.		142217-69-4	49

Phenol tablets

This product is a compound preparation. Each tablet contains 500 mg of acetaminophen and 65 mg of caffeine. Excipients are: corn starch, microcrystalline cellulose, Opadry, cross-linked polyvinyl pyrrolidone, polyvinyl pyrrolidone, magnesium stearate, methylparaben, propylparaben, isoascorbic acid, and carnauba wax.

Name	Description	Content	CAS NO.	Registered Holders
Acetaminophen	It can inhibit the synthesis of prostaglandins and produce antipyretic and analgesic effects More It can inhibit the synthesis of prostaglandins and produce antipyretic and analgesic effects	500mg	103-90-2	68
Caffeine	It is a central nervous system stimulant that can constrict cerebral blood vessels and reduce the amplitude of its pulsation. It can enhance the analgesic effect when combined with antipyretic analgesics. More It is a central nervous system stimulant that can constrict cerebral blood vessels and reduce the amplitude of its pulsation. It can enhance the analgesic effect when combined with antipyretic analgesics.	65mg		0

Phenol tablets

This product is a compound preparation. Each tablet contains 500 mg of acetaminophen and 65 mg of caffeine. Excipients are: corn starch, microcrystalline cellulose, Opadry, cross-linked polyvinyl pyrrolidone, polyvinyl pyrrolidone, magnesium stearate, methylparaben, propylparaben, isoascorbic acid, and carnauba wax.

Name	Description	Content	CAS NO.	Registered Holders
Acetaminophen	It can inhibit the synthesis of prostaglandins and produce antipyretic and analgesic effects More It can inhibit the synthesis of prostaglandins and produce antipyretic and analgesic effects	500mg	103-90-2	68
Caffeine	It is a central nervous system stimulant. Since it can constrict cerebral blood vessels and reduce the amplitude of its pulsation, it can enhance the analgesic effect when combined with antipyretic analgesics. More It is a central nervous system stimulant. Since it can constrict cerebral blood vessels and reduce the amplitude of its pulsation, it can enhance the analgesic effect when combined with antipyretic analgesics.	65mg		0

Aminamimin tablets Ⅱ

This product is a compound preparation. Day tablets (acetaminophen pseudoephedrine tablets): Each tablet contains 500 mg of acetaminophen, 30 mg of pseudoephedrine hydrochloride, and 15 mg of dextromethorphan hydrobromide. Night tablets (aminophen tablets II): Each tablet contains 500 mg of acetaminophen, 30 mg of pseudoephedrine hydrochloride, 15 mg of dextromethorphan hydrobromide, and 2 mg of chlorpheniramine maleate.

Name	Description	Content	CAS NO.	Registered Holders
Acetaminophen	It can inhibit the synthesis of prostaglandins and has antipyretic and analgesic effects More It can inhibit the synthesis of prostaglandins and has antipyretic and analgesic effects	500mg	103-90-2	68
(1S,2S)-(+)-Pseudoephedrine hydrochloride	It has the effect of shrinking the capillaries in the upper respiratory tract, eliminating congestion in the nasopharyngeal mucosa, and relieving nasal congestion and runny nose. More It has the effect of shrinking the capillaries in the upper respiratory tract, eliminating congestion in the nasopharyngeal mucosa, and relieving nasal congestion and runny nose.	30mg		0
Dextromethorphan hydrobromide monohydrate	Can inhibit the cough center and has an antitussive effect More Can inhibit the cough center and has an antitussive effect	15mg		0
Chlorphenamine maleate	It is an antihistamine that can further relieve symptoms such as nasal congestion, runny nose, sneezing, and has a sedative and sleep-inducing effect. More It is an antihistamine that can further relieve symptoms such as nasal congestion, runny nose, sneezing, and has a sedative and sleep-inducing effect.	2mg	113-92-8	28

Aminophene and pseudoephedrine tablets

This product is a compound preparation. Each tablet contains the main ingredients of acetaminophen 500 mg, dextromethorphan hydrobromide 15 mg and pseudoephedrine hydrochloride 30 mg.

Name	Description	Content	CAS NO.	Registered Holders
Acetaminophen	Produces antipyretic and analgesic effects by inhibiting the formation of prostaglandins More Produces antipyretic and analgesic effects by inhibiting the formation of prostaglandins	500mg	103-90-2	68
(1S,2S)-(+)-Pseudoephedrine hydrochloride	It can shrink the capillaries in the upper respiratory tract, eliminate congestion in the nasopharyngeal mucosa, and relieve nasal congestion symptoms. More It can shrink the capillaries in the upper respiratory tract, eliminate congestion in the nasopharyngeal mucosa, and relieve nasal congestion symptoms.	30mg		0
Dextromethorphan hydrobromide monohydrate	Can inhibit the cough center and has an antitussive effect More Can inhibit the cough center and has an antitussive effect	15mg		0