It competes with p-aminobenzoic acid for dihydrofolate synthase, inhibiting bacterial synthesis of dihydrofolate; when used in combination with trimethoprim and sulfadiazine, it has a dual blocking effect on the bacterial synthesis of tetrahydrofolate, enhancing the antibacterial effect and reducing drug-resistant strains.

It competes with p-aminobenzoic acid for dihydrofolate synthase, inhibiting bacterial synthesis of dihydrofolate; when used in combination with trimethoprim and sulfamethoxazole, it has a dual blocking effect on the bacterial synthesis of tetrahydrofolate, enhancing the antibacterial effect and reducing drug-resistant strains.

By inhibiting bacterial dihydrofolate reductase, it prevents dihydrofolate from being reduced to tetrahydrofolate; when used in combination with sulfamethoxazole and sulfadiazine, it has a dual blocking effect on the bacterial synthesis of tetrahydrofolate, enhancing the antibacterial effect and reducing drug-resistant strains

①Analgesic effect: It is mainly through inhibiting the synthesis of prostaglandins and other substances that can make pain sensitive to mechanical or chemical stimulation (such as bradykinin, histamine), and it is a peripheral analgesic. However, the possibility of central analgesia (possibly acting on the hypothalamus) cannot be ruled out; ②Anti-inflammatory effect: The exact mechanism is still unclear. It may be due to the fact that this product acts on inflamed tissues and inhibits the synthesis of prostaglandins or other substances that can cause inflammatory reactions (such as histamine) to play an anti-inflammatory role. Inhibition of the release of lysosomal enzymes and leukocyte chemotaxis may also be related to it; ③Antipyretic effect: It may act on the hypothalamic thermoregulatory center to cause peripheral vasodilation, increased skin blood flow, sweating, and increased heat dissipation to play an antipyretic role. This central effect may be related to the inhibition of prostaglandin synthesis in the hypothalamus; ④Anti-rheumatic effect: The anti-rheumatic mechanism of this product, in addition to antipyretic and analgesic effects, is mainly anti-inflammatory; ⑤Inhibition of platelet aggregation: It works by inhibiting platelet cyclooxygenase and reducing the production of prostaglandins.

This product is an intermediate in the synthesis of Schisandrae Chinensis A, which can reduce liver damage and alanine aminotransferase (ALT) elevation caused by carbon tetrachloride, inhibit liver microsomal lipid peroxidation caused by carbon tetrachloride, and carbon tetrachloride metabolic conversion to carbon monoxide, reduce the consumption of reduced coenzyme II and oxygen in the process of carbon tetrachloride metabolism, and protect the structure and function of liver cell biomembrane; it can reduce the increase of liver ALT induced by prednisone, and promote liver regeneration in mice with partial hepatectomy; it has a significant induction effect on cytochrome P450 enzyme activity, and enhances the detoxification ability of carbon tetrachloride and certain carcinogens; it has an effect on improving protein metabolism in some hepatitis patients, increasing albumin and reducing globulin. It has no negative conversion effect on HbsAg and HbeAg, and cannot shrink enlarged liver and spleen.

White or light yellow powder; sweet taste, no moldy smell; hygroscopic; aqueous solution has acidic reaction