 Home > Encyclopedia > 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1) structure

CAS No:
163680-77-1
Formula:
C16H15FN2O4.CH4O3S
Chemical Name:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
Synonyms:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-,methanesulfonate (1:1);7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-,(S)-,monomethanesulfonate;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-,monomethanesulfonate;T 3762;Pazufloxacin mesilate;Pazufloxacin methanesulfonate;Pasil;Pazucross;Pazufloxacin mesylate
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

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Description

Crystalline Solid

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1) Basic Attributes

Molecular Weight：

414.41

Exact Mass：

414.089691

EC Number：

1308068-626-2

HScode：

29349990

Characteristics

PSA：

156

XLogP3：

3.02510

Appearance：

crystalline solid

Melting Point：

258-259 °C (decomp)

Boiling Point：

531.5°C at 760 mmHg

Flash Point：

275.2ºC

Storage Conditions：

-20°C Freezer

Vapor Pressure：

4E-12mmHg at 25°C

Specific rotation：

D20 -64.2° (c = 1 in 1.0N NaOH)

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

36/37/38-34-11

safety instructions：

26-45-36/37/39-16

RTECS Number：

UU8815400

Marks：

Xi,C,F

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1) Use and Manufacturing

A fluorinated quinolone antibiotic. Antibacterial.

Drug Function and Efficacy

This product belongs to the quinolone antibacterial drug. Its main mechanism of action is to inhibit the activity of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus, hinder DNA synthesis and cause bacterial death; it has a weak inhibitory effect on human topoisomerase II. This product has the characteristics of a broad antibacterial spectrum and strong antibacterial effect. It has good antibacterial activity against G+ bacteria such as Staphylococcus, Streptococcus, Enterococcus, and against G- bacteria such as Escherichia coli, Proteus mirabilis, Klebsiella, Enterobacter cloacae, Citrobacter rodentium, Acinetobacter calcoaceticus, Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, etc. This product also has good antibacterial activity against some anaerobic bacteria such as Clostridium perfringens, Fusobacterium nucleatum, Propionibacterium acnes, Porphyromonas, some Peptostreptococci, Bacteroides fragilis and Prevotella.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pazufloxacin Mesylate Injection
Ingredients	Pazufloxacin mesylate. Chemical name: (-)-(s)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-[1,4]benzoxazine-6-carboxylic acid methanesulfonate. Chemical structure: Molecular formula: C16H15FN2O4CH4O4S Molecular weight: 414.41
Indication	(1) This product can inhibit the metabolism of theophylline in the liver, increasing the blood concentration of theophylline. Symptoms of theophylline poisoning, such as gastrointestinal reactions, headaches, arrhythmias, and spasms, may occur. Therefore, patients need to be closely observed. When the two drugs are used together, the blood concentration of theophylline should be closely observed. (2) When this product is used in combination with phenylacetic acid, diacetyl ketoacids, and non-steroidal anti-inflammatory analgesics, spasms may occur. Therefore, close observation is required. If symptoms occur, the drug should be discontinued immediately and antispasmodic treatment should be taken. When spasms occur, the combination of the two drugs should be terminated, the airway should be kept open, and antispasmodic drugs should be used for treatment. (3) When this product is used in combination with warfarin, it can enhance the effect of warfarin and thus prolong the coagulation time. Therefore, close observation and coagulation time test should be performed when using the drug. (4) When this product is used in combination with propanesulfonic acid, the serum half-life is prolonged and the AUC is increased, but there is no significant change in the peak blood concentration.
Specifications	20ml:0.3g (based on pazufloxacin)
Manufacturer	Sichuan Meida Kangjiale Pharmaceutical Co., Ltd.

Pazufloxacin Mesylate Sodium Chloride Injection
Ingredients	【Ingredients】Pazufloxacin mesylate. Chemical name: (-)-(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid methanesulfonate. Chemical structure: Molecular formula: C16H15FN2O4·CH4O3S Molecular weight: 414.41
Indication	1. This product can inhibit the metabolism of theophylline in the liver, increase the blood concentration of theophylline, and may cause symptoms of theophylline poisoning, such as gastrointestinal reactions, headaches, arrhythmias, spasms, etc., so patients need to be closely observed, and the blood concentration of theophylline should be closely observed when the two drugs are used together. 2. This product may cause spasms when used in combination with phenylacetic acid, diethyl ketoacids, and non-steroidal anti-inflammatory analgesics, so it should be closely observed. If symptoms occur, the drug should be discontinued immediately and spasmolytic treatment should be taken. When spasms occur, the combination of the two drugs should be terminated. Keep breathing unobstructed and use spasm-relieving drugs for treatment. 3. When this product is used in combination with warfarin, it can enhance the effect of warfarin, thereby prolonging the coagulation time, so it should be closely observed and a coagulation time test should be performed when using the drug. 4. When this product is used in combination with propanesulfonic acid, the serum half-life is prolonged and the AUC increases, but there is no significant change in the peak blood concentration.
Specifications	100ml: 0.3g pazufloxacin and 0.85g sodium chloride
Manufacturer	Hunan Zhengqing Pharmaceutical Co., Ltd.

Pazufloxacin mesylate
Manufacturer	Suzhou Wanqing Pharmaceutical Co., Ltd.

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Registered Holders

Yibin Hongguang Pharmaceutical Co., Ltd.

China
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Suicheng Pharmaceutical Co., Ltd.

China
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Suzhou Wanqing Pharmaceutical Co., Ltd.

China
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Guide of 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)

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