Henan Guangkang Pharmaceutical Co., Ltd.

This product is a nitrofuran antibacterial drug. It has certain antibacterial effects on both Gram-positive and Gram-negative bacteria, including Salmonella, Shigella, Escherichia coli, Klebsiella pneumoniae, Enterobacter, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Vibrio cholerae, Campylobacter, Bacteroides, etc. It is also active against Trichomonas and Giardia at a certain concentration. Its mechanism of action is to interfere with bacterial oxidoreductase and thus block the normal metabolism of bacteria.

This product is a macrolide antibiotic. Its mechanism of action is similar to that of erythromycin, and its antibacterial spectrum is also similar to that of erythromycin, but its antibacterial activity against most Gram-positive bacteria is slightly worse. Some erythromycin-resistant Staphylococcus aureus are still sensitive to kitasamycin. This product also has considerable activity against diphtheria, tetani, Neisseria gonorrhoeae, pertussis, Rickettsia and Chlamydia trachomatis.

By blocking the membrane transport of calcium ions in myocardial and vascular smooth muscle, inhibiting the influx of calcium ions into cells, it causes a decrease in myocardial contractility and vasodilation. Animal experiments have shown that by reducing myocardial contractility and peripheral vascular resistance, myocardial oxygen consumption is reduced; by dilating coronary vessels and developing collateral circulation, the oxygen supply to myocardial ischemic sites is increased; by inhibiting the consumption of high-energy phosphate compounds, the ability to resist hypoxia is enhanced.

It has high antibacterial activity against common aerobic Gram-positive bacteria, such as Staphylococcus aureus (including those resistant to penicillin G), Staphylococcus epidermidis, β-hemolytic Streptococcus, viridans Streptococcus and Streptococcus pneumoniae. It has good antibacterial effect on anaerobic bacteria, including Clostridium diphtheriae, and Clostridium perfringens. It has no activity against Gram-negative bacteria such as enterococci, meningococci, Neisseria gonorrhoeae, and Haemophilus influenzae, as well as fungi. There is no cross-resistance between this product and penicillin, chloramphenicol, cephalosporins and tetracyclines, and there is partial cross-resistance with macrolides. This product acts on the 50S subunit of the ribosome of sensitive bacteria, preventing the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. It is generally an antibacterial agent, but at high concentrations, it also has a bactericidal effect on certain bacteria.

It reduces peripheral vascular resistance, increases cardiac output, reduces venous pressure, activates fibrinolysis, reduces fibrinogen levels, prevents platelet aggregation, promotes the synthesis of pyrimidine nucleosides (NAD and NADP), increases the concentration of adenine nucleosides (AMP, ADP and ATP), and finally hinders lipolysis, reducing elevated cholesterol and triglyceride levels