Heilongjiang Longgui Pharmaceutical Co., Ltd.

It has a strong antibacterial effect on most anaerobic bacteria, and its bactericidal mechanism has not yet been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, thereby acting on the DNA metabolism process of bacteria and promoting cell death.

It is a long-acting nonsteroidal anti-inflammatory analgesic. After entering the body, it is metabolized into diphenyl ethyl ester, which can inhibit the activity of cyclooxygenase, reduce the synthesis of prostaglandins, and produce anti-inflammatory, analgesic and antipyretic effects.

It has special effects on the following bacteria: Staphylococcus (Staphylococcus aureus, Staphylococcus epidermidis and penicillin-resistant bacteria), Streptococcus (Group A hemolytic streptococcus, non-hemolytic streptococcus and Streptococcus pneumoniae), Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis (indole-negative) and indole-positive Proteus, Haemophilus influenzae and Haemophilus conjunctivitis, Moraxella conjunctivitis, Acinetobacter calcoaceticus (Herellea vaginacola), Neisseria. Bacteria resistant to gentamicin are still sensitive to tobramycin. No bacteria resistant to tobramycin have been found so far, but long-term use may lead to bacterial resistance.

This product belongs to the macrolide antibiotics. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), all groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, certain spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on certain bacteria at high concentrations. It can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site ("P" site), blocking the transfer RNA (t-RNA) from binding to the "P" site, and also blocking the self-acceptor site ("A" site) of the polypeptide chain.