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Erythromycin

Erythromycin structure

CAS No:
114-07-8
Formula:
C37H67NO13
Chemical Name:
Erythromycin
Synonyms:
Erythromycin;Erythromycin A;Oxacyclotetradecane,erythromycin deriv.;Dotycin;Erycin;Erythrocin;Erythrogran;Pantomicina;Oxacyclotetradecane-2,10-dione,4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-,[3R-(3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)]-;Erycinum;Abboticin;Ilotycin;[3R-(3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)]-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione;E-Mycin;Erytab;Erycette;Theramycin Z;T-Stat;Emgel;Erythromast 36;Erythromid;Erymax;Abomacetin;Erycen;ERYC;Retcin;Staticin;PCE;Aknin;Inderm;Ak-Mycin;Ermycin;Erygel;EMU;Torlamicina;E-Base;Erythro;Stiemycin;EryDerm;NSC 55929;Vetwic;Eritrex;Eritromed;7540-22-9;47879-92-5;47880-49-9;47879-97-0;50976-86-8;374700-25-1;775573-41-6;797051-71-9;856313-44-5
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Erythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.Target: AntibacterialErythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often prescribed for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and legione

Erythromycin Basic Attributes

Molecular Weight：

733.93

Exact Mass：

733.93

EC Number：

204-040-1

HScode：

2941500000

Characteristics

PSA：

194

XLogP3：

1.78560

Appearance：

Fluffy colorless powder

Density：

1.2±0.1 g/cm3

Melting Point：

40-135 °C

Boiling Point：

818.4°C at 760 mmHg

Flash Point：

448.8±34.3 °C

Refractive Index：

1.535

Water Solubility：

soluble in water at 2mg/ml;ethanol: soluble

Storage Conditions：

0-6ºC

Vapor Pressure：

4.94E-31mmHg at 25°C

Specific rotation：

-74.5 º (c=2, ethanol)

Safety Information

Hazard category：

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R42/43

safety instructions：

S24-S37-S45

RTECS Number：

KF4375000

Marks：

Xn:Harmful

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Erythromycin Use and Manufacturing

Methods of Manufacturing

Produced by fermentation of Streptomyces erythreus. Obtained by butyl acetate extraction and cooling crystallization.

Uses

Erythromycin can affect bacterial protein synthesis and is generally effective against gram-positive bacteria. It is mainly used to treat infections caused by penicillin G-resistant Staphylococcus aureus. Erythromycin is a commonly used macrolide antibiotic. Its antibacterial spectrum is similar to penicillin. It is mainly used for patients allergic to penicillin or for infections of Staphylococcus aureus resistant to penicillin. It can also be used for streptococcus, pneumococcal infections and diphtheria carrier. This product is an intermediate of macrolide antibiotic derivatives, which belongs to antibacterial antibiotics, and its antibacterial spectrum is similar to penicillin.

Computed Properties

Molecular Weight:733.9
XLogP3:2.7
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:733.46124119
Monoisotopic Mass:733.46124119
Topological Polar Surface Area:194
Heavy Atom Count:51
Complexity:1180
Defined Atom Stereocenter Count:18
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Butyl acetate

Ethyl acetate

Formaldehyde

Lactic acid

Glucose

Ethanol

Acetone

1-Propanol

Erythromycin thiocyanate

Starch

Downstream Products

Erythromycin thiocyanate

Roxithromycin

Clarithromycin

Azithromycin

Price Analysis

Make your Erythromycin purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Erythromycin prices .

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Orange peel syrup
Ingredients	Molecular weight: C37H67NO13
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	500ml per bottle

Erythromycin ointment
Ingredients	Each vial of this product contains 80,000 units of erythromycin as the main ingredient and yellow vaseline as the auxiliary material.
Indication	1. It has antagonistic effects with chloramphenicol and lincomycin, so its co-use should be avoided. 2. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	1%

Erythromycin Capsules
Ingredients	The main ingredient is erythromycin.
Indication	1. This product can inhibit the metabolism of anti-epileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations and toxic reactions. Combination with fentanyl can inhibit the metabolism of the latter and prolong its duration of action. Combination with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combination with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. This product has an antagonistic effect with chloramphenicol and lincosamides, and it is not recommended to use them at the same time. 3. This product is an antibacterial agent and can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as the treatment of meningitis, the two should not be used at the same time. 4. Patients who take warfarin for a long time can prolong the prothrombin time when using this product, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used at the same time, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5Except for dihydroxypropylphylline, the simultaneous use of this product with xanthine drugs can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of combined use, and the reduction in aminophylline clearance is proportional to the serum peak value of this product. Therefore, the dose of xanthine drugs should be adjusted during and after the combination of the two. 6This product may enhance hepatotoxicity when used in combination with other hepatotoxic drugs. 7The combination of large doses of this product with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8When used in combination with lovastatin, its metabolism can be inhibited and blood concentrations can be increased, which may cause rhabdomyolysis; when used in combination with midazolam or triazolam, the clearance of both can be reduced and their effects can be enhanced.
Specifications	0.25 g (250,000 units) of erythromycin
Manufacturer	Hainan Boda Pharmaceutical Factory

See More Related Drugs

Registered Holders

ALEMBIC PHARMACEUTICALS LTD

United States
Active
CALYX CHEMICALS AND PHARMACEUTICALS LTD

United States
Active
POLFA TARCHOMIN

United States
Active

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