It is a penicillin antibiotic. When combined with sulbactam sodium, it is not only protected from enzymatic hydrolysis, but also has a wider antibacterial spectrum, with good antibacterial activity against enzyme-producing strains of Staphylococcus, Acinetobacter and Bacteroides fragilis. It has antibacterial activity against Staphylococcus, Streptococcus, Pneumococcus, Enterococcus, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Fusobacterium, Peptococcus, Peptostreptococcus and Bacteroides including Bacteroides fragilis.

It is a semi-synthetic β-lactamase inhibitor, which has strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus, but has poor effects on other bacteria. However, it has strong and irreversible competitive inhibition against β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. When combined with ampicillin sodium, it expands the antibacterial spectrum and has good antibacterial activity against enzyme-producing strains of Staphylococcus aureus, Acinetobacter and Bacteroides fragilis.

This product is a semi-synthetic β-lactamase inhibitor, which has strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus, and has poor effects on other bacteria, but has strong irreversible competitive inhibition of β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. When used in combination with penicillins and cephalosporins, it can reduce the MIC of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Bacteroides fragilis, etc., which are resistant to the first two types of antibiotics due to enzyme production, to within the sensitive range. This product has a strong affinity for PBP1 of Bacillus mirabilis and PBP2 of Acinetobacter calcoaceticus.

Unspecified

1. It has a positive inotropic effect on the myocardium, mainly acting on beta 1 receptors, and has relatively little effect on beta 2 and alpha receptors; 2. It can directly excite cardiac beta 1 receptors to enhance myocardial contraction and increase stroke volume, thereby increasing cardiac output; 3. It can reduce peripheral vascular resistance (reduced afterload), but systolic blood pressure and pulse pressure generally remain unchanged, or only increase due to increased cardiac output; 4. It can reduce ventricular filling pressure and promote atrioventricular node conduction; 5. Myocardial contractility is enhanced, and coronary blood flow and myocardial oxygen consumption often increase; 6. Due to increased cardiac output, renal blood flow and urine volume often increase; 7. Unlike dopamine, dobutamine does not act indirectly through the release of endogenous norepinephrine, but directly on the heart.

Ampicillin sodium is a broad-spectrum semi-synthetic penicillin. This product has a strong antibacterial effect on hemolytic streptococci, Streptococcus pneumoniae and non-penicillinase-producing Staphylococci, which is similar to or slightly inferior to penicillin. Ampicillin also has a good antibacterial effect on viridans streptococci, and is better than penicillin on enterococci and Listeria. This product has antibacterial activity against Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces, Haemophilus influenzae, Bordetella pertussis, Neisseria and anaerobic bacteria except Bacteroides fragilis. Some Proteus mirabilis, Escherichia coli, Salmonella and Shigella are sensitive to this product. Ampicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.