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Ampicillin sodium

Ampicillin sodium structure

CAS No:
69-52-3
Formula:
C16H19N3O4S.Na
Chemical Name:
Ampicillin sodium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1),(2S,5R,6R)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-,monosodium salt,D-(-)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-,monosodium salt,[2S-[2α,5α,6β(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt,(2S,5R,6R)-;Ampicillin sodium;Penbritin S;Sodium P-50;Sodium 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;Sodium 6-[D-α-aminophenylacetamido]penicillanoate;Sodium ampicillin;Ampicillin sodium salt;Binotal sodium;Sodium D-α-aminobenzylpenicillanate;Sodium binotal;D-α-Aminobenzylpenicillin sodium salt;Polycillin N;Monosodium ampicillin;Ampicillin-Na;Anhypen;Britapen injection;Sodium ampicillinate;Ampicin;Principen N;Omnipen N;Alpen N;Pen A/N;Amcill S;Pentrex;Cilleral;Ampi-Dry 5000;Solampi;Pamecil;Totacillin N;24863-47-6;57748-55-7
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

Ampicillin sodium Basic Attributes

Molecular Weight：

371.39

Exact Mass：

371.091583

EC Number：

200-708-1

HScode：

29419000

Characteristics

PSA：

138

XLogP3：

1.35

Appearance：

white with slight yellow cast powder

Melting Point：

215 °C (dec.)(lit.)

Boiling Point：

683.9°C at 760 mmHg

Water Solubility：

Freely soluble in water. Sparingly soluble in acetone;H2O: 50 mg/mL, clear, very faintly yellow

Storage Conditions：

2-8°C

Toxicity：

Oral-Rat LD50:> 5314 mg/kg; Oral-Mouse LD50:> 5314 mg/kg

Flammability characteristics：

Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gas

Specific rotation：

Optical rotation = +287.9 deg at 20 °C (C=1 in H2O)

Odor：

Odorless or has a faint odor characteristic of the penicillins

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

42/43-36/37/38-22

safety instructions：

22-36/37-45-36-26

RTECS Number：

XH8400000

Marks：

Xi,Xn

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

The stability of ampicillin sodium in soln is concn dependent and decreased as the concn of the drug increases. Ampicillin sodium appears to be especially susceptible to inactivation in soln containing dextrose, which appears to have a catalytic effect on hydrolysis of the drug.

Precautionary statement(s)：

P261-P280-P342 + P311

Hazard Statements：

H317-H334

Toxicity

Toxicity class：

practically nontoxic

Ampicillin sodium Use and Manufacturing

Methods of Manufacturing

Derived from ampicillin salt: Suspend ampicillin in water, adjust pH to 9 with sodium hydroxide solution, dissolve, and filter. The filtrate is decolorized with activated carbon, filtered, and the filtrate is dried at low temperature to obtain a product.

Uses

diuretic, anti-hypertensive

Material

Sodium hydroxide

Ethyl acetate

Isooctanoic acid

Isopropanol

Drug Function and Efficacy

Broad-spectrum semi-synthetic penicillin has a broad-spectrum killing effect on gram-positive and gram-negative bacteria. It has a strong antibacterial effect on hemolytic streptococci, pneumococci and non-penicillinase-producing staphylococci, which is similar to or slightly inferior to penicillin. It also has a good antibacterial effect on viridans streptococci, and is better than penicillin on enterococci and listeria. It is effective against Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces, Haemophilus influenzae, Bordetella pertussis and Neisseria.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ampicillin Sodium and Cloxacillin Sodium for Injection
Ingredients	This product is a compound preparation, its components are ampicillin sodium and cloxacillin sodium.
Indication	1 This product is incompatible with aminoglycosides, norepinephrine, metaraminol, phenobarbital, B vitamins, vitamin C and other drugs, and should not be dripped in the same bottle. 2 Probenecid can reduce the renal tubular secretion of cloxacillin and prolong the serum half-life of this product. 3 Aspirin and sulfonamides inhibit the binding of this product to serum proteins and increase the free blood concentration of this product. 4 Ampicillin and kanamycin have synergistic antibacterial effects on Escherichia coli and Proteus. 5 This product should be dripped alone and should not be dripped in the same bottle with the following drugs: aminoglycosides, clindamycin phosphate, lincomycin hydrochloride, polymyxin B, succinylcholine,
Specifications	0.5g
Manufacturer	Shanxi Shuangyan Pharmaceutical Co., Ltd.

Ampicillin Sodium for Injection
Ingredients	The main ingredient of this product is ampicillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-〔(R)-2-amino-2-phenylacetylamino〕-7-oxo-4-thia-1-azabicyclo［3.2.0］heptane-2-carboxylic acid sodium salt.
Indication	1. Combination with probenecid will prolong the half-life of this product. 2. Ampicillin and kanamycin have synergistic antibacterial effects against Escherichia coli and Proteus. 3. This product should be dripped alone and should not be dripped in the same bottle with the following drugs: aminoglycosides, clindamycin phosphate, lincomycin hydrochloride, polymyxin B, succinic acid chloramphenicol, erythromycin, epinephrine, metaraminol, dopamine, atropine, calcium gluconate, B vitamins, vitamin C, nutritional injections containing amino acids, and hydrocortisone succinate, etc. 4. Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. 5. Ampicillin can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives.
Specifications	1.0g (calculated as C16H19N3O4S)
Manufacturer	Sichuan Pharmaceutical, Inc.

Ampicillin Sodium for Injection
Ingredients	The main ingredient of this product is ampicillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-〔(R)-2-amino-2-phenylacetylamino〕-7-oxo-4-thia-1-azabicyclo［3.2.0］heptane-2-carboxylic acid sodium salt.
Indication	1. Combination with probenecid will prolong the half-life of this product. 2. Ampicillin and kanamycin have synergistic antibacterial effects against Escherichia coli and Proteus. 3. This product should be dripped alone and should not be dripped in the same bottle with the following drugs: aminoglycosides, clindamycin phosphate, lincomycin hydrochloride, polymyxin B, succinic acid chloramphenicol, erythromycin, epinephrine, metaraminol, dopamine, atropine, calcium gluconate, B vitamins, vitamin C, nutritional injections containing amino acids, and hydrocortisone succinate, etc. 4. Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. 5. Ampicillin can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives.
Specifications	Calculated as C16H19N3O4S 1.0g
Manufacturer	Hunan Tiansheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

North China Pharmaceutical Group Semisyntech Co.,Ltd.

Japan
Active
Sandoz GmbH

Austria
Active
ACS DOBFAR S. P. A.

Brazil
Active

See More Registered Holders

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