Histamine H2 receptor antagonist, which has an inhibitory effect on the secretion of gastric acid and pepsin and can reduce the production of gastric acid

Antacids, which neutralize stomach acid that has already been produced

Antacids, which neutralize stomach acid that has already been produced

Omeprazole is a racemic mixture of a pair of active optical enantiomers. It reduces gastric acid secretion through a highly targeted mechanism of action and is a special inhibitor of the acid pump in gastric parietal cells. This product acts rapidly, and a once-daily dose can reversibly inhibit gastric acid secretion. Omeprazole is a weakly alkaline substance that is concentrated and converted into active substances in the highly acidic environment of the tubules in gastric parietal cells, inhibiting H, K-ATPase (proton pump). This inhibitory effect on the final step of gastric acid formation is dose-related, and highly inhibits basal gastric acid secretion and irritant gastric acid secretion, but has nothing to do with irritants. Intravenous administration of omeprazole in humans inhibits gastric acid secretion in a dose-related manner. The inhibitory effect of omeprazole on gastric acid secretion is related to the area under the drug-time curve (AUC), but not to the blood drug concentration at the time of administration. Omeprazole combined with antibiotics can eradicate Helicobacter pylori, which is associated with rapid relief of symptoms, high gastric mucosal repair rate and long-term relief of peptic ulcer disease, thereby reducing complications such as gastrointestinal bleeding, and also reducing the need for long-term treatment with anti-acid drugs.

By acting on the smooth muscle of the coronary and peripheral blood vessels and the atrioventricular node, inhibiting the influx of Ca2 into the cells, it shows the effect of vasodilation and prolonging the conduction time of the atrioventricular node, thus being effective for hypertension, arrhythmia, and angina pectoris. 1. Effect on blood pressure: reduce hypertension, reduce peripheral vascular resistance and myocardial oxygen consumption, increase cardiac output, and reduce blood pressure and show sodium diuresis without reducing the blood flow to the brain, coronary arteries, and kidneys. 2. Effect on arrhythmia: prolong the conduction time, effective refractory period, and functional refractory period of the atrioventricular node, show effects on supraventricular tachyarrhythmia, and inhibit supraventricular tachyarrhythmia caused by atrial electrical stimulation. 3. Effect on myocardial ischemia: improve the balance of myocardial oxygen supply and demand, dilate the main trunk and side branches of the coronary arteries, increase blood flow in the ischemic part of the myocardium, and inhibit coronary artery spasm. The myocardial protective effect is manifested in inhibiting excessive influx of Ca2 into cells during myocardial ischemia, maintaining cardiac function and myocardial energy metabolism, and shrinking the infarct focus.

Erythromycin stearate belongs to the macrolide antibiotics, and has antibacterial activity against Staphylococcus, various groups of Streptococcus and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. Erythromycin stearate is only effective against bacteria that actively divide.

It achieves antibacterial effect by inhibiting the activity of bacterial DNA gyrase and hindering the replication of bacterial DNA. It has the characteristics of broad antibacterial spectrum and strong antibacterial effect, and has good antibacterial effect on most Enterobacteriaceae, Gram-negative bacteria, some Gram-positive bacteria, Legionella, Mycoplasma, Chlamydia, but has poor effect on anaerobic bacteria and enterococci.