Hunan Hansen Pharmaceutical Co., Ltd.

1. It has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobic bacteria. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus, etc. Actinomycetes, Lactobacillus and Propionibacterium are resistant to this product. Its bactericidal concentration is slightly higher than the inhibitory concentration. 2. It can also inhibit the redox reaction of amoeba and break the nitrogen chain of protozoa. When the drug concentration is 1-2 mg/L, the morphology of Amoeba histolytica can change in 6-20 hours and all of them will be killed within 24 hours. When the concentration is 0.2 mg/L, Amoeba histolytica can be killed within 72 hours. 3. It has a strong effect of killing trichomonas, and its mechanism is unknown. It has a carcinogenic effect on some animals.

Restores the imbalance between the excitation and inhibition processes of the cerebral cortex, and has central inhibitory effects such as sedation, hypnosis and analgesia

The contrast-producing substance in diatrizoate injection is a diatrizoate salt, in which tightly bound iodine absorbs X-rays.

There is no clear single pharmacological action mentioned, but as a binding component of diatrizoate it participates in the overall contrast effect.

The contrast-producing substance in diatrizoate injection is a diatrizoate salt, in which tightly bound iodine absorbs X-rays.

1 Pharmacology The substance that produces the contrast effect in diatrizoate injection is a diatrizoate, in which the firmly bound iodine absorbs X-rays. 2 Toxicology Systemic toxicity Based on the results of acute toxicity studies, no risk of acute poisoning was found with the use of diatrizoate injection. Animal studies on systemic tolerance with repeated daily intravenous administration did not find any results that were unfavorable to the usually one-time diagnostic use in humans. Potential genotoxicity, carcinogenicity Studies on genotoxicity did not find diatrizoate to have a mutagenic effect in vivo or in vitro. Based on the above results, and taking into account the metabolic stability of diatrizoate and the one-time diagnostic use of diatrizoate injection, it is believed that diatrizoate injection has no carcinogenic risk to humans. Local tolerance and contact sensitization possibility Local tolerance studies did not show that diatrizoate injection had local adverse reactions to blood vessels, or mucous membranes or serosal membranes in the human body. Mild to moderate local intolerance reactions may occur if diatrizoate injection is accidentally injected into blood vessels or into other tissues.