Zinc is an important component of many enzymes in the body and has the functions of promoting growth and development, improving taste, etc. When it is deficient, growth stagnation, reproductive inability, difficulty in wound healing, body weakness, conjunctivitis, stomatitis, glossitis, lack of appetite, chronic diarrhea, loss of taste, and neurological symptoms may occur. Zinc is particularly important for the growth and development of children.

Zinc is an important component of many enzymes in the body and has the functions of promoting growth and development, improving taste, etc. When it is deficient, growth stagnation, reproductive inability, difficulty in wound healing, body weakness, conjunctivitis, stomatitis, glossitis, lack of appetite, chronic diarrhea, loss of taste, and neurological symptoms may occur. Zinc is particularly important for the growth and development of children.

This product is a guanine nucleoside analog that has an inhibitory effect on hepatitis B virus (HBV) polymerase. It can be converted into an active triphosphate through phosphorylation, and the half-life of the triphosphate in the cell is 15 hours. By competing with the natural substrate of HBV polymerase, deoxyguanosine triphosphate, entecavir triphosphate can inhibit all three activities of viral polymerase (reverse transcriptase): (1) HBV polymerase initiation; (2) formation of pregenomic mRNA reverse transcription negative strand; (3) synthesis of HBVDNA positive strand. The inhibition constant (Ki) of entecavir triphosphate on HBVDNA polymerase is 0.0012μM. Entecavir triphosphate has a weak inhibitory effect on cellular α, β, δDNA polymerase and mitochondrial γDNA polymerase, with Ki values ranging from 18 to 160μM.

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