After oral absorption, this product slowly decomposes into formaldehyde and ammonia in acidic urine. Formaldehyde has a bactericidal effect. Ammonia can easily alkalinize urine, so it is necessary to take acidifying urine drugs such as ammonium chloride when taking it.

After oral absorption, this product slowly decomposes into formaldehyde and ammonia in acidic urine. Formaldehyde has a bactericidal effect. Ammonia can easily alkalinize urine, so it is necessary to take acidifying urine drugs such as ammonium chloride when taking it.

It has both α-receptor and β-receptor stimulating effects. Alpha-receptor stimulating causes vasoconstriction of the skin, mucous membranes, and visceral vessels. β-receptor stimulating causes coronary vasodilation, skeletal muscle, myocardial excitation, increased heart rate, and relaxation of bronchial smooth muscle and gastrointestinal smooth muscle. The effect on blood pressure is dose-related. Common doses increase systolic blood pressure while diastolic blood pressure does not increase or decreases slightly. High doses increase both systolic and diastolic blood pressure.

Etoposide is an effective component of lignans isolated from podophyllin. VP-16 is a cell cycle-specific anti-tumor drug that acts in the late S phase or G2 phase. Its action site is topoisomerase II, forming a stable cleavable complex between drug, enzyme and DNA, interfering with DNA topoisomerase II, making the damaged DNA unable to be repaired. By stabilizing the DNA breakage complex, it causes double-line breaks in DNA and topoisomerase II. It activates certain endonucleases in vivo, or acts on DNA through its metabolites, and its non-glycoside homologue 4-demethylepipodophyllotoxin can inhibit microtubule assembly.

No specific pharmacological information is provided