Shanghai Yurui BIOTECHNOLOGY (Anyang) Pharmaceutical Co., Ltd.

This product is a piperazine calcium channel antagonist that can block calcium influx into vascular smooth muscle, causing vasodilation and improving cerebral and coronary circulation, especially having a certain selective effect on cerebral blood vessels. This product can inhibit phosphodiesterase, prevent cAMP from decomposing into inactive 5-AMP, thereby increasing the intracellular cAMP concentration, inhibiting the release of histamine, 5-hydroxytryptamine, bradykinin and other biologically active substances, and also inhibiting the activation of complement C4.

The antipsychotic effect is mainly related to its blocking of dopamine receptors (DA2) in the mesolimbic system and mesocortical pathways related to emotional thinking, while blocking the alpha-adrenaline receptors in the reticular formation ascending activation system is related to the sedative and tranquilizing effect. This product has a strong antiemetic effect and a weak sedative effect.

Broad-spectrum antiviral drug. It has the effect of inhibiting the growth of multiple viruses such as respiratory syncytial virus, influenza virus, hepatitis A virus, adenovirus, etc. in vitro, and its mechanism is not fully understood. After entering the virus-infected cells, the drug is rapidly phosphorylated, and its product acts as a competitive inhibitor of viral synthase, inhibiting inosine monophosphate dehydrogenase, influenza virus RNA polymerase and mRNA guanosine transferase, thereby causing a decrease in intracellular guanosine triphosphate, impairing viral RNA and protein synthesis, and inhibiting viral replication and transmission. It may also have an immune effect and neutralizing antibody effect on respiratory syncytial virus.

Tetracycline antibiotics are broad-spectrum antibacterial agents with bactericidal effects at high concentrations. They are sensitive to Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria, and spirochetes; they are more effective against Gram-positive bacteria than Gram-negative bacteria, but Enterococci are resistant to them; they are sensitive to Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, and Yersinia. They have certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant Neisseria gonorrhoeae are also resistant to them. Due to years of widespread use, common clinical pathogens are seriously resistant to them.

Reduce peripheral vascular resistance, increase cardiac output, reduce venous pressure, activate fibrinolysis, reduce fibrinogen levels, prevent platelet aggregation, promote the synthesis of pyrimidine nucleosides (NAD and NADP), increase the concentration of adenine nucleosides (AMP, ADP and ATP), hinder lipolysis, and reduce elevated cholesterol and triglyceride levels