Aripiprazole orally disintegrating tablets
Function and Efficacy
Pharmacological action Aripiprazole has high affinity for D2, D3, 5-HT1A, and 5-HT2A receptors, and moderate affinity for D4, 5-HT2C, 5-HT7, α1, H1 receptors, and 5-HT reabsorption sites. Aripiprazole is a partial agonist of D2 and 5-HT1A receptors, and an antagonist of 5-HT2A receptors. Like other drugs with anti-schizophrenia effects, the mechanism of action of aripiprazole is still unclear. However, it is believed to be mediated by partial agonism of D2 and 5-HT1A receptors and antagonism of 5-HT2A receptors. The action with other receptors may produce some other clinical effects of aripiprazole, such as the antagonism of α1 receptors, which can explain its phenomenon of postural hypotension.
Ingredients
The main ingredient of this product is aripiprazole. Chemical name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)quinolinone
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| AripiprazoleIngredients |
It has high affinity for D2, D3, 5-HT1A, and 5-HT2A receptors, and moderate affinity for D4, 5-HT2C, 5-HT7, α1, H1 receptors, and 5-HT reabsorption sites. It is a partial agonist of D2 and 5-HT1A receptors, and an antagonist of 5-HT2A receptors. Its mechanism of action may be mediated by partial agonism of D2 and 5-HT1A receptors and antagonism of 5-HT2A receptors. The action with other receptors may produce some other clinical effects, such as the antagonism of α1 receptors, which can explain the phenomenon of postural hypotension. More |
129722-12-9 | 82 |
Appearance
This product is white or off-white tablets.
Indication
For the treatment of schizophrenia. The efficacy of aripiprazole in the treatment of schizophrenia was established in short-term (4-week and 6-week) controlled trials in patients with schizophrenia. Physicians who select aripiprazole for long-term treatment should periodically reassess the long-term efficacy of this drug for individual patients.
Usage and Dosage
For patients who switch to this product from other antipsychotics: some patients can stop the antipsychotics they were using immediately; while other patients should gradually stop the antipsychotics they were using when starting to use it. The time for taking antipsychotics at the same time should be minimized. Adults: Oral, once a day. The initial dose is 10 mg. After 2 weeks of medication, the dose can be gradually increased according to the individual's efficacy and tolerance, up to a maximum of 30 mg. Thereafter, this dose can be maintained unchanged. The maximum daily dose should not exceed 30 mg. Dosage: Keep your hands dry, quickly take out the tablet and place it on the tongue. Aripiprazole orally disintegrating tablets disintegrate within seconds, without the need for water or with only a small amount of water. It takes effect by swallowing into the stomach. Patients should not try to separate or chew the tablets.
Adverse Reactions
The safety of aripiprazole was evaluated in multiple-dose, premarketing studies involving 5592 patients with schizophrenia, mania in bipolar disorder, and dementia due to Alzheimer's disease; exposure was approximately 3639 case-years. A total of 1887 patients were treated with aripiprazole for at least 180 days, and 1251 were treated for at least 1 year. Because the characteristics of the patients and other factors vary from those in clinical trials, the data in the following tables cannot be used to predict the incidence of adverse reactions in ordinary medical practice. Likewise, the frequencies cited cannot be compared with data obtained from other clinical investigations involving different treatments, uses, and investigators. However, the data cited do provide some basis for the physician to evaluate the effects of drug and nondrug factors on the study subjects.
Precautions
Patients with known hypersensitivity to this product are contraindicated.
Special Population Medication
Precautions for children: There is currently a lack of sufficient clinical experience in children. Precautions for pregnancy and lactation: It is not clear whether this product is safe for pregnant women to take. For pregnant women, the pros and cons should be weighed to decide whether to take this product. It can only be used when the potential benefits outweigh the risks, otherwise it should not be taken during pregnancy and lactation. Precautions for the elderly: Aripiprazole is well tolerated by the elderly at the recommended dose and no dose adjustment is required.
Drug Interactions
1 The risk of using this product in combination with other drugs has not been systematically evaluated. In view of the effects of this product on the central nervous system, caution should be exercised when it is used in combination with other drugs and alcohol that act on the central nervous system. 2 Because it antagonizes α1-adrenergic receptors, aripiprazole has the potential to enhance the effects of certain antihypertensive drugs. 3 Aripiprazole is not a substrate for CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or CYP2E1 enzymes, and does not undergo direct glucuronidation. This indicates that there is no possibility of interaction between aripiprazole and inhibitors or inducers of these enzymes, or other factors (such as smoking). 4n
Storage
Store in sealed container. Valid for 24 months
Packaging Specification
5 mg
Validity Period
24 months
Manufacturer
Chengdu Kanghong Pharmaceutical Group Co., Ltd.
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Founded in:
1996-10-03 -
Address:
No. 108, Shuxi Road, Jinniu District, Chengdu, Sichuan -
Tax NO.:
91510100633116839D -
Registered Funds:
919.463954 million yuan -
Website:
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Email: