Tolbutamide Tablets

This product is a hypoglycemic drug. 1. It stimulates the pancreatic islet β cells to secrete insulin, provided that the islet β cells still have a certain ability to synthesize and secrete insulin; 2. It inhibits hepatic glycogenolysis and gluconeogenesis by increasing portal vein insulin levels or acting directly on the liver, reducing the generation and output of glucose by the liver; 3. It may also increase the sensitivity of extrapancreatic tissues to insulin and the utilization of sugar (probably mainly through post-receptor effects), so the overall effect is to reduce fasting blood sugar and postprandial blood sugar.

The main ingredient is tolbutamide, and its chemical name is: 4-methyl-N-[(butylamino)carbonyl]benzenesulfonamide.

This product is white tablets.

It is suitable for mild and moderate type 2 diabetes mellitus that is not effectively controlled by diet alone. The patient's pancreatic β cells have a certain insulin secretion function and there are no serious complications.

The usual oral dosage is 0.5g at a time, 1-2g per day. Start by taking 0.5g before breakfast or before breakfast and lunch, or 0.25g, three times a day, half an hour before meals. Gradually increase the dosage according to the condition. The general dosage is 1.5g per day, and the maximum dosage is 3g per day.

There may be diarrhea, nausea, vomiting, headache, stomach pain or discomfort; 1. Less common is rash; 2. Rare but serious symptoms include jaundice, liver damage, bone marrow suppression, granulocytopenia (manifested as sore throat, fever, infection), thrombocytopenia (manifested as bleeding, purpura), etc.

The following situations should not use it: 1. Type Ⅰ diabetic patients; 2. Type Ⅱ diabetic patients accompanied by ketoacidosis, coma, severe burns, infection, trauma and major surgery and other stressful situations; 3. People with liver and kidney dysfunction; 4. People who are allergic to sulfonamides; 5. Patients with leukopenia.

1. When taken with alcohol, it can cause abdominal cramps, nausea, vomiting, headache, facial flushing and hypoglycemia. 2. When used with beta-blockers, it can increase the risk of hypoglycemia and mask the symptoms of hypoglycemia, such as increased pulse rate and blood pressure; the possibility of causing this situation is small when using a small amount of selective beta-blockers such as atenolol and metoprolol. 3. Chloramphenicol, guanethidine, insulin, monoamine oxidase inhibitors, phenylbutazone, hydroxyphenylbutazone, probenecid, salicylates, sulfonamides and this product can enhance the hypoglycemic effect. 4. Adrenal cortical hormones, epinephrine, phenytoin sodium, thiazide diuretics, and thyroxine can increase blood sugar levels. When used with this class of drugs, the dosage of this class of drugs may need to be increased. 5. When coumarin anticoagulants are used with this class of drugs, the plasma concentrations of each other will increase at first, but then the plasma concentrations of each other will decrease, so the dosage of both needs to be adjusted.

Keep away from light and store in sealed container.

0.5g

Sinopharm Medicine Holding Xingsha Pharmaceutical (Xiamen) Co., Ltd.

• Founded in:

  1998-12-30

• Address:

  No. 36, Xinmei Road, Haicang District, Xiamen

• Tax NO.:

  91350200155005287Q

• Registered Funds:

  360 million yuan

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