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Yanhuning for injection

Function and Efficacy

This product is an extract of the plant Andrographis paniculata - andrographolide, which is refined through esterification, dehydration and salt formation to form dehydrated andrographolide succinic acid half-ester potassium sodium salt. It is the same substance as the active metabolite of Andrographolide in the body. Non-clinical pharmacological studies of andrographolide have shown that: 1. This product has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins, can promote the disappearance of fever, and the effect is rapid and can last for more than 4 hours; 2. This product can counteract the increased permeability of capillary walls caused by xylene or histamine; 3. This product can shorten the sleep latency of mice caused by sodium pentobarbital, prolong their sleep time, and can also enhance the effect of subthreshold sodium pentobarbital to induce sleep in mice. The test results indicate that this product has a significant sedative effect; 4. This product can significantly promote the adrenal cortex function of rats and increase the body's emergency response to pathogen infection; 5. Clinical etiological diagnosis experiments and tissue culture inactivation experiments show that this product has a certain inactivation effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type III, type IV, and enterosyncytial virus (Rsv) in vitro.

Ingredients

Yanhuning

Name Description Content CAS NO. Manufacturer
PotassiuM sodiuM Dehydroandrographolide SuccinateIngredients

This product is a potassium sodium salt of dehydrated andrographolide succinate half ester made by esterification, dehydration and salt formation of andrographolide, an extract of the plant Andrographis paniculata. It is the same substance as the active metabolite of Andrographolide in the body. It has the effects of antipyretic, anti-inflammatory, sedative and enhancing the body's emergency response ability; it has a certain inactivation effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type Ⅲ, type Ⅳ, and enterosyncytial virus (RSV) in vitro.

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863319-40-8 43

Indication

Suitable for viral pneumonia and viral upper respiratory tract infection.

Usage and Dosage

Before use, add an appropriate amount of sterile injection water to dissolve. 1. Intramuscular injection: 40-80 mg once, 1-2 times a day; 2. Intravenous drip: dilute with 5% glucose injection or 5% glucose sodium chloride injection and then drip intravenously, 0.16-0.4 g per day, 1-2 times a day. 3. For children, reduce the dosage or follow the doctor's advice.

Adverse Reactions

There are few reports on the clinical application of Yanhuning, and allergic reactions such as rashes are occasionally seen. Yanhuning and Chuanhuning have the same active metabolite in the body. Literature reports that the adverse reactions observed after Chuanhuning was put on the market include: 1. Allergic reactions. It can manifest as rash, itching, maculopapular rash, and even dyspnea, edema, and anaphylactic shock in severe cases, which often occur after the first use of the drug; 2. Digestive tract reactions. Nausea, vomiting, diarrhea, and liver damage have also been reported; 3. Blood system reactions. Leukopenia, thrombocytopenia, purpura, etc. can be seen; 4. Pyrogenic reactions. Chills, high fever, and even dizziness, chest tightness, palpitations, tachycardia, and decreased blood pressure.

Precautions

1. Those who are allergic to this product are prohibited from using this product. 2. Pregnant women are prohibited from using this product.

Special Population Medication

Precautions for children: Reduce dosage for children or follow doctor's advice. Precautions for pregnancy and lactation: This product has cytotoxic effects on placental chorionic trophoblast cells, and animal tests show that it has anti-early and mid-pregnancy effects, so it is contraindicated for pregnant women. Precautions for the elderly: Use with caution or follow doctor's advice.

Drug Interactions

1. This product should not be used in combination with acidic or alkaline drugs or drugs containing sodium bisulfite or sodium pyrosulfite as antioxidants. 2. This product should not be used in combination with aminoglycosides or quinolones.

Storage

Keep tightly closed in a cool, dry place.

Packaging Specification

40mg

Validity Period

One year

Manufacturer

Hunan Yige Pharmaceutical Co., Ltd.

  • Founded in:

    2001-11-29
  • Address:

    No. 1689, North Second Ring Road, Yuhu District, Xiangtan City
  • Tax NO.:

    914303001846834827
  • Registered Funds:

    46.3575 million yuan
  • Website:

  • Email:

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