Sucralfate chewable tablets

Pharmacological action: The mechanism of action of sucralfate in promoting the healing of gastric and duodenal ulcers is still not very clear. It is known that it mainly exerts its efficacy through local rather than systemic effects, and is related to the following effects: 1. Both human clinical and ulcer animal model studies have shown that sucralfate can bind to exudate proteins in the ulcer site to form a complex attached to the ulcer surface. 2. In in vitro tests, sucralfate-albumin membrane has a barrier effect that inhibits H diffusion. 3. In clinical studies, patients taking the recommended dose of sucralfate during the treatment of ulcers can reduce the activity of pepsin in gastric juice by 32%. 4. Sucralfate can absorb bile salts in in vitro tests. The above results suggest that sucralfate exerts its anti-ulcer effect by forming a complex attached to the ulcer surface, protecting the ulcer site from damage by gastric acid, pepsin and bile salts. 1g of sucralfate can neutralize approximately 14-16mEq of gastric acid. Toxicological studies: Reproductive toxicity: When rats were given sucralfate at a dose of 38 times the human dose, fertility was not significantly affected. When rats, mice and rabbits were given 50 times the human dose, no teratogenic effect on the animal fetus was observed. Due to the lack of adequate and strictly controlled clinical research data on the use of this product in pregnant women, and the results of animal reproductive toxicity studies cannot fully represent the results of human trials, pregnant women can only take this product when it is really necessary. Carcinogenicity: Rats and mice were given sucralfate 1g/kg (12 times the human dose) orally for 24 consecutive months, and the results showed no carcinogenicity.

Sucralfate

This product is white tablets.

Gastric and duodenal ulcers.

Chew and take one hour before meals and before going to bed. Adults, 1.0g each time, 3 to 4 times a day. The course of treatment is 4 to 6 weeks, or as directed by the doctor.

Dry mouth and constipation may occur. Rare or occasional adverse reactions include low back pain, diarrhea, dizziness, indigestion, nausea, rash, itching, stomach cramps, insomnia, drowsiness and hypophosphatemia.

It is contraindicated for those who are allergic to this product or have habitual constipation.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Not yet clear.

1. This product can interfere with and affect the absorption of tetracycline, phenytoin, digoxin, warfarin, cimetidine, quinolones, and fat-soluble vitamins when taken at the same time. Therefore, the above drugs should be taken 2 hours apart. 2. When used in combination with multi-enzyme tablets, the efficacy of both drugs is reduced. 3. If you are taking other medicines, please consult a doctor or pharmacist before using this product.

Keep sealed.

1g

24 months

NORTHEAST Pharmaceutical Group Shenyang NO.1 Pharmaceutical Co., Ltd.

• Founded in:

  1989-01-25

• Address:

  No. 8 Kunming Lake Street, Shenyang Economic and Technological Development Zone

• Tax NO.:

  91210106242656694M

• Registered Funds:

  80 million yuan

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