Streptomycin Sulfate for Injection

Streptomycin sulfate is an aminoglycoside antibiotic. Streptomycin has a strong antibacterial effect on Mycobacterium tuberculosis, and its minimum inhibitory concentration is generally 0.5 mg/ml. Most non-tuberculous mycobacteria are resistant to this product. Streptomycin also has antibacterial effects on many Gram-negative bacilli such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Salmonella, Shigella, Brucella, Pasteurella, etc.; Neisseria meningitidis and Neisseria gonorrhoeae are also sensitive to this product. Streptomycin has poor effects on Staphylococcus and other Gram-positive cocci. All groups of streptococci, Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product. Streptomycin mainly binds to the 30S subunit of the bacterial ribosome and inhibits the synthesis of bacterial proteins. Bacteria are very likely to develop drug resistance after contact with streptomycin. The combined use of streptomycin and other antibacterial drugs or anti-tuberculosis drugs can reduce or delay the development of drug resistance.

The main ingredient of this product is streptomycin sulfate.

1. This product is mainly used in combination with other anti-tuberculosis drugs for the initial treatment of various tuberculosis cases caused by Mycobacterium tuberculosis, or other sensitive mycobacterial infections. 2. This product can be used alone to treat tularemia, or in combination with other antibacterial drugs for the treatment of plague, inguinal granuloma, brucellosis, rat-bite fever, etc. 3. It can also be combined with penicillin or ampicillin to treat endocarditis caused by viridans streptococci or enterococci.

1. Common dosage for adults (1) Intramuscular injection, 0.5 g (calculated as streptomycin, the same below), once every 12 hours, combined with other antibacterial drugs; bacterial (green streptococcus) endocarditis, intramuscular injection, 1 g every 12 hours, combined with penicillin, for 1 week, followed by 0.5 g every 12 hours for 1 week; patients over 60 years old should reduce the dosage to 0.5 g every 12 hours for 2 weeks. (2) Enterococcal endocarditis, intramuscular injection, combined with penicillin, 1 g every 12 hours for 2 weeks, followed by 0.5 g every 12 hours for 4 weeks. (3) Plague, intramuscular injection, 0.5-1 g once every 12 hours, combined with tetracycline, the course of treatment is 10 days. (4) Tularemia, intramuscular injection, 0.5-1 g every 12 hours, continuous

1. Symptoms of nephrotoxicity such as hematuria, decreased frequency of urination or decreased urine volume, loss of appetite, thirst, etc., and in a few cases, increased blood urea nitrogen and creatinine levels may occur. 2. Symptoms such as unsteady gait and dizziness may occur when the vestibular function is affected; hearing loss, tinnitus, and fullness in the ears may occur when the auditory nerve is affected. 3. Some patients may experience peripheral neuritis symptoms such as numbness and tingling in the face or limbs. 4. Occasionally, vision loss (optic neuritis) and neuromuscular blockade symptoms such as drowsiness, weakness, and difficulty breathing may occur. 5. Occasionally, rash, itching, redness, and swelling may occur. A few patients may still experience ototoxic symptoms such as hearing loss, tinnitus, and fullness in the ears after stopping the drug, which should be paid attention to.

It is contraindicated in patients allergic to streptomycin or other aminoglycosides.

Precautions for children: This product belongs to the aminoglycoside class and should be used with caution in pediatrics, especially for premature infants and newborns whose renal tissue is not fully developed, which prolongs the half-life of this class of drugs and makes them easily accumulate in the body and produce toxic reactions. Precautions for pregnancy and lactation: This product belongs to Class D for pregnant women, which means it is harmful to humans, but the benefits may outweigh the disadvantages after use. This product can cross the placenta and enter the fetal tissue. It has been reported that pregnant women have caused hearing damage to the fetus after using this product. Therefore, pregnant women must fully weigh the pros and cons before using this product. Lactating women should suspend breastfeeding during medication. Precautions for the elderly: Elderly patients are prone to various toxic reactions after using aminoglycosides, and blood drug concentrations should be monitored as much as possible during the course of treatment. Elderly patients have a certain degree of physiological decline in renal function, and a smaller therapeutic dose should be used even if the renal function test values are within the normal range.

1. The combination of this product with other aminoglycosides or the sequential local or systemic application may increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. The combination of this product with neuromuscular blocking drugs may aggravate neuromuscular blocking effects. The combination of this product with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), etc., or the sequential local or systemic application may increase ototoxicity and nephrotoxicity. 3. The combination of this product with cephalothin or cefazolin, either topically or systemically, may increase nephrotoxicity. 4. The combination of this product with polymyxin injections, or the sequential local or systemic application may increase nephrotoxicity and neuromuscular blocking effects. 5. Other nephrotoxic and ototoxic drugs should not be used together with this product or applied sequentially to avoid aggravating nephrotoxicity or ototoxicity.

Keep tightly closed in a dry place.

1.0g

36 months

Liaoning PHARMA-UNION Pharmaceutical Co., Ltd.

• Founded in:

  2008-05-12

• Address:

  122A Xianghuai Road, Benxi Economic Development Zone

• Tax NO.:

  91210500673786474R

• Registered Funds:

  110 million yuan

• Email:

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