Oxacillin Sodium for Injection

This product is an acid-resistant and penicillinase-resistant penicillin. Oxacillin has good antibacterial activity against penicillinase-producing Staphylococci, but its antibacterial activity against various streptococci and non-penicillinase-producing Staphylococci is inferior to penicillin G. Oxacillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

Oxacillin sodium. Its chemical name is: (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt monohydrate. Molecular formula: C19H18N3Na05Sbull;H20. Molecular weight: 441.44

This product is only suitable for the treatment of penicillinase-producing staphylococcal infections, including sepsis, endocarditis, pneumonia, and skin and soft tissue infections, etc. It can also be used for mixed infections caused by pyogenic Streptococcus or pneumococcus and penicillin-resistant staphylococci.

1 For intramuscular injection, add 2.8ml of sterile water for injection for every 0.5g. For intramuscular injection, adults take 4-6g per day, divided into 4 doses; for intravenous drip, adults take 4-8g per day, divided into 2-4 doses. For severe infection, the daily dose can be increased to 12g. 2 For children weighing less than 40kg, give 12.5-25mg/kg every 6 hours according to body weight, and for those weighing more than 40kg, give adult doses. For newborns weighing less than 2kg, give 25mg/kg every 12 hours for those aged 1-14 days, and 25mg/kg every 8 hours for those aged 15-30 days; for those weighing more than 2kg, give 25mg/kg every 8 hours for those aged 1-14 days, and 25mg/kg every 6 hours for those aged 15-30 days. 3 Patients with mild and moderate renal impairment do not need to adjust the dose. Patients with severe renal impairment should avoid using large doses to prevent central nervous system toxicity.

1. Allergic reaction: urticaria and other types of rashes are common, leukopenia, interstitial nephritis, asthma attacks and serum sickness reactions are rare; anaphylactic shock is occasionally seen. Once it occurs, it must be rescued on the spot, and treatment measures such as keeping the airway open, oxygen inhalation, and the use of epinephrine and glucocorticoids are given. 2. Intravenous use of this product may occasionally cause nausea, vomiting and elevated serum aminotransferase. 3. Large doses of intravenous infusion of this product may cause convulsions and other central nervous system toxic reactions. 4. There are reports of infants developing hematuria, proteinuria and uremia after using large doses of this product.

1. It is contraindicated for patients with a history of allergy to penicillins or those with a positive penicillin skin test; 2. It should be used with caution in pregnant and lactating women; 3. It should be used with caution in newborns, especially premature infants.

Precautions for children: Use with caution in newborns, especially premature infants. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women.

1. This product is incompatible with aminoglycosides, norepinephrine, metahydroxylamine, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of oxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides can inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.

Keep tightly closed in a dry place.

Calculated as C19H19N3O5S 0.5g

Youcare Pharmaceutical Group Co., Ltd.

• Founded in:

  2001-08-14

• Address:

  No. 6, Hongda Middle Road, Beijing Economic and Technological Development Zone, Beijing

• Tax NO.:

  911100007263731643

• Registered Funds:

  450 million yuan

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