Secnidazole tablets

Secnidazole enters the microorganism by passive diffusion, and destroys the DNA of microorganisms and anaerobic cells through the reduction of 5-nitroimidazole. The mechanism of action is similar to other 5-nitroimidazole drugs. Pharmacodynamic studies have shown that secnidazole has extremely strong selective toxicity to Trichomonas protozoa and anaerobic microorganisms. Toxicological effects: Animal experiments have not shown that this product has teratogenic effects, but like other 5-nitroimidazole drugs, this product should be avoided as much as possible in the first three months of pregnancy.

The main ingredient is: Secnidazole. The chemical name is: 1-(2-hydroxypropyl)-2-methyl-5-nitroimidazole hemihydrate.

This product is white, off-white or slightly yellow tablets.

Nitroimidazole antiprotozoal drugs. Mainly used to treat the following diseases: urethritis and vaginitis caused by Trichomonas vaginalis; intestinal amebiasis; hepatic amebiasis; giardiasis.

Usage: Oral, before meals. Dosage: 1 Urethritis and vaginitis caused by Trichomonas vaginalis: Adults, 2g, single dose. Spouses should take it at the same time. 2 Intestinal amoebiasis Symptomatic acute amoebiasis: Adults: 2g, single dose; Children: 30mg/kg, single dose. Asymptomatic acute amoebiasis: Adults: 2g once, once a day, for 3 consecutive days; Children: 30mg/kg once, once a day, for 3 consecutive days. 3 Hepatic amoebiasis: Adults: 1.5g per day, orally once or in divided doses, for 5 consecutive days; Children: 30mg/kg once, orally once or in divided doses, for 5 consecutive days. 4 Giardiasis: Children, 30mg/kg, single dose.

Common adverse reactions include metallic taste in the mouth. Occasional adverse reactions include digestive tract disturbances (such as nausea, vomiting, diarrhea, abdominal pain), skin allergic reactions (such as rash, urticaria, itching), dark urine, and leukopenia (return to normal after discontinuation of the drug). Rare adverse reactions include dizziness, headache, and moderate neurological dysfunction.

The following patients are contraindicated: 1. Those who are allergic to secnidazole or general nitroimidazole drugs; 2. Pregnant and lactating women.

Precautions for children: Children over 12 years old can take this product, and the single dose of this product is 30mg/kg, or it can be used under the guidance of a doctor. Precautions for pregnancy and lactation: Women who are pregnant or may become pregnant are prohibited from taking this product; after oral absorption, this product can pass through the placental barrier and enter the breast milk, so lactating women should avoid breastfeeding during medication. Precautions for the elderly: There is currently no information on the use of this product for people over 65 years old.

1. This product can cause delirium or mental disorder when taken together with disulfiram (also known as anabolic sulfamethoxazole). Do not drink alcohol during treatment with this product or at least within one day after taking the medicine to avoid disulfiram-like reactions. 2. This product has a strong inhibitory effect on the anticoagulant effect of warfarin, so patients with a history of abnormal blood counts should not take it.

Keep in a sealed container

0.25g

24 months