Erythromycin

Cyclic erythromycin belongs to the macrolide antibiotic class. It acts on the 50S subunit of bacterial cell ribosomes and inhibits bacterial protein synthesis. Cyclic erythromycin is a semi-synthetic derivative of erythromycin. The introduction of a cyclic carbonate group greatly improves the lipophilicity of erythromycin, thereby increasing its absorption. Experiments have shown that this structural change reduces serum protein binding, improves antibacterial activity and reduces toxicity.

Infections caused by sensitive bacteria, such as tonsillitis, pharyngitis, bacterial pneumonia, mycoplasma pneumonia, stomatitis, Legionnaires' disease, diphtheria, whooping cough, scarlet fever, erythrasma, erysipelas, gonorrhea, early syphilis, chancroid, urethritis, Campylobacter enteritis, amoebic enteritis, etc.

Take once every 12 hours on an empty stomach. 　　Adults: 500-750mg (2-3 tablets) for the first dose, followed by 250-500mg every 12 hours. The dose can be doubled for patients with severe infection. 　　Children: 30mg/kg body weight for the first dose, followed by 15mg/kg body weight every 12 hours.

When erythromycin is taken with the following drugs at the same time, drug interactions may occur. 1. Theophylline: The serum concentration and toxicity of theophylline will increase. Patients receiving this drug at the same time should reduce the dosage of theophylline. 2. Digoxin: The serum concentration and absorption of digoxin will increase. 3. Cyclosporine A: The serum concentration and renal toxicity of cyclosporine A will increase. 4. Coumarin anticoagulants: The effects of this type of drug will increase. 5. When erythromycin is used in combination with lincomycin or clindamycin, antagonism will occur.

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