Compound Mebendazole Tablets

This compound preparation is a broad-spectrum anthelmintic. The pharmacological effects of its components are as follows: ① Mebendazole is a broad-spectrum anthelmintic that can inhibit the uptake of glucose by intestinal parasites, leading to the depletion of glycogen in the worm body and reducing the formation of adenosine triphosphate in the worm body. However, it does not affect the glucose level in the host's blood. Ultrastructural observation shows that mebendazole causes microtubule degeneration in the cytoplasm of the worm's membrane cells and intestinal cells, resulting in the accumulation of Golgi endocrine granules. Transport blockage, cytoplasmic dissolution, and complete degeneration of absorptive cells lead to the death of the worm body. Mebendazole has the effect of completely killing hookworm eggs and whipworm eggs and partially killing ascaris eggs. In vitro tests have shown that 5 mg/L can inhibit the development of hookworm larvae. ② Levamisole hydrochloride can selectively inhibit succinate dehydrogenase in the worm body muscle, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the worm body muscle and reducing energy production. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm body. Levamisole also has immunomodulatory and immune excitation functions.

1. Tobacillus thiocyanate Chemical name: Benzophenone guanidine methyl ester Molecular formula: C16H13N3O3 Molecular weight: 295.29 2. Levamisole hydrochloride Chemical name: (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride Molecular formula: C11H12N2S.HCl Molecular weight: 240.75

This product is a pink tablet.

Used to treat pinworm disease, ascariasis, hookworm disease, whipworm disease, strongyloidiasis, and tapeworm disease.

Oral 1. To expel pinworms: 1 tablet at a time, repeat the medication once after 2 weeks and 4 weeks. 2. To expel ascarids: 2 tablets at a time. 3. To expel whipworms, hookworms, or mixed infections of ascarids, whipworms, and hookworms: 1 tablet at a time, twice a day, for 3 consecutive days. For patients under 44 years old, the dosage is halved.

Due to low absorption and rapid excretion, there are few adverse reactions. Very few patients have gastrointestinal irritation symptoms, such as nausea, abdominal discomfort, abdominal pain, diarrhea, fatigue, and rash. Occasionally, exfoliative dermatitis and systemic alopecia are seen. All can recover to normal on their own.

This drug has been shown to cause teratogenicity in animal experiments, so it is contraindicated in pregnant women and children under 2 years old.

Not yet clear.

Keep sealed.

Mebendazole 0.1g, levamisole hydrochloride 25mg

Sichuan Deyuan Pharmaceutical Group Co., Ltd.

• Founded in:

  2001-02-19

• Address:

  No. 518, Haozikou Road, Central District, Neijiang City

• Tax NO.:

  915110007232358235

• Registered Funds:

  30.28 million yuan

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