Glipizide Extended Release Tablets

This product is a sulfonylurea antidiabetic drug, which is effective for most patients with type 2 diabetes. It can reduce fasting and postprandial blood sugar and reduce glycosylated hemoglobin (HbAlc) by 1% to 2%. The main function of this type of drug is to stimulate pancreatic β cells to secrete insulin, but the prerequisite is that pancreatic β cells still have a certain function of synthesizing and secreting insulin. Its mechanism is to specifically bind to the sulfonylurea receptors on the β cell membrane, thereby closing the K channel, causing changes in membrane potential, opening the Ca2 channel, and increasing intracellular Ca2, which promotes insulin secretion. In addition, there are extra-pancreatic effects, including improving the insulin resistance of peripheral tissues (such as liver, muscle, and fat).

Glipizide

It is suitable for patients with mild to moderate type 2 diabetes who have not achieved satisfactory results with diet control and physical exercise for 2 to 3 months. The pancreatic beta cells of such diabetic patients must have a certain insulin secretion function, and have no acute complications (such as infection, trauma, ketoacidosis, hyperosmolar coma, etc.), no pregnancy, and no serious chronic complications.

Oral: Take the medicine once a day. Start with 5 mg a day, taken at breakfast (or at other convenient times). Adjust the dose based on weekly blood sugar levels or bimonthly glycated hemoglobin levels. Most patients can take 10 mg a day, some patients need to take 15 mg, and the maximum daily dose is 20 mg.

This product has relatively few adverse reactions. 1. Endocrine and metabolic system: This product belongs to the sulfonylurea class of drugs, and the main adverse reaction of this class of drugs is hypoglycemia. 2. Digestive system: (1) Digestive tract reactions such as nausea, vomiting, upper abdominal burning sensation, loss of appetite, diarrhea, and metallic taste in the mouth may occur. These reactions are generally not serious and are related to excessive dosage. Sometimes they can increase appetite and cause weight gain. (2) Liver damage: Jaundice and abnormal liver function are rare. 3. Blood system: Adverse reactions of the blood system are rare, including leukopenia, agranulocytosis, anemia, and thrombocytopenia. 4. Allergic reactions: such as rash, and occasionally exfoliative dermatitis.

1. Those who are allergic to sulfonamides. 2. Patients with confirmed diagnosis of type 1 diabetes. 3. Patients with type 2 diabetes accompanied by stressful conditions such as ketoacidosis, coma, severe burns, infection, trauma, and major surgery. 4. Patients with impaired liver and kidney function. 5. Patients with leukopenia.

Precautions during pregnancy and lactation: 1. Animal experiments and clinical observations have shown that sulfonylurea hypoglycemic drugs can cause stillbirth and fetal malformation, so they are contraindicated for use by pregnant women. 2. This type of drug can be excreted through breast milk, so it is not suitable for nursing mothers to use it to avoid hypoglycemia in infants. Precautions for the elderly: Use with caution in the elderly.

1. Combination with the following drugs may increase the occurrence of hypoglycemia. (1) Drugs that inhibit the excretion of sulfonylureas (SU) in the urine, such as probenecid and allopurinol for the treatment of gout. (2) Drugs that slow down the metabolism of SU, such as alcohol, H2 receptor blockers (cimetidine, ranitidine), chloramphenicol, the antifungal drug miconazole, and anticoagulants. Sulfonylureas and alcohol taken together can cause abdominal pain, nausea, vomiting, headache, and facial flushing (especially when used with chlorpropamide). When used in combination with coumarin anticoagulants, the plasma concentrations of both drugs increase at first, and then decrease. Therefore, the dosage of the two drugs should be adjusted according to the situation. (3) Drugs that promote the separation of SU from bound plasma albumin, such as salicylates and lipid-lowering drugs fibrates. (4) Drugs that have

Keep away from light and store in sealed container.

5 mg