Hydrocortisone injection

This product is a glucocorticoid with anti-inflammatory, immunosuppressive, antitoxin and anti-shock effects. (1) Anti-inflammatory effect: It has an effect on inflammation caused by various causes except viruses. Glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the symptoms of inflammation. They can also inhibit the repair of tissues in the later stages of inflammation and reduce sequelae. (2) Immunosuppressive effect: It prevents or inhibits cell-mediated immune responses, delayed allergic reactions, and reduces the expansion of primary immune responses. (3) Anti-toxic and anti-shock effects: Glucocorticoids can improve the body's tolerance, reduce cell damage, and play a role in protecting the body. It also has the effects of dilating blood vessels, enhancing myocardial contractility, and improving microcirculation.

The main ingredient of this product is: hydrocortisone.

This product is a suspension of fine particles. The fine particles sink after standing and become a uniform milky white suspension after shaking.

It is used for adrenal insufficiency and hypopituitarism, allergic and inflammatory diseases, and rescue of critical toxic infections.

Intramuscular injection: 20-40 mg per day, intravenous drip: 100 mg once a day. Before use, dilute with 25 times sodium chloride injection or 5% glucose injection 500 ml and then drip intravenously, and add 0.5-1 g of vitamin C at the same time.

This product generally has no obvious adverse reactions when using physiological dose replacement therapy. Adverse reactions mostly occur when using pharmacological doses, and are closely related to the course of treatment, dosage, type of medication, usage and route of administration. Common adverse reactions are as follows: 1. Long-term use may cause the following side effects: iatrogenic Cushing's syndrome face and body shape, weight gain, lower limb edema, purple lines, bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, long bone pathological fractures), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and aggravation of diabetes. 2. Patients may experience mental symptoms: euphoria, agitation, delirium, restlessness, disorientation, and may also manifest as inhibition. Psychiatric symptoms are particularly prone to occur in people with chronic wasting diseases and those who have had mental disorders in the past. 3. Concurrent infection is the main adverse reaction of adrenocortical hormones. Fungi, tuberculosis, Staphylococcus, Proteus, Pseudomonas aeruginosa and various herpes viruses are the main ones. 4. Glucocorticoid withdrawal syndrome: Sometimes patients experience dizziness, fainting tendency, abdominal pain or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after stopping the drug. If careful examination can rule out adrenocortical insufficiency and recurrence of the original disease, it can be considered as a glucocorticoid dependence syndrome.

Patients who are allergic to this product and other steroid hormones are prohibited from using it. Patients with the following diseases should not use it in general. In special cases, the pros and cons should be weighed, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fractures, trauma repair period, corneal ulcer, hyperadrenocortical syndrome, hypertension, diabetes, pregnant women, fungal infections that cannot be controlled by antibiotics, chickenpox, measles, severe osteoporosis, etc.

Precautions for children: Children should be very cautious when using adrenocortical hormones for a long time. Exceptions are adrenocortical hypofunction and congenital adrenal hyperplasia. Precautions for pregnancy and lactation: 1. Medication during pregnancy: This product can pass through the placenta. Animal experimental studies have confirmed that administration during pregnancy can increase the incidence of cleft palate, placental insufficiency, spontaneous abortion and intrauterine growth retardation. It can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. 2. Medication during lactation: Since this product can be excreted in breast milk, it has adverse effects on infants, such as growth inhibition and adrenal cortical function inhibition. 3. Pregnant and lactating women should avoid using it as much as possible after weighing the pros and cons. Precautions for the elderly: Elderly patients are prone to hypertension and diabetes when using glucocorticoids. Elderly patients, especially postmenopausal women, are prone to aggravating osteoporosis when using glucocorticoids.

1. Non-steroidal anti-inflammatory analgesics can enhance the effect of this product on gastrointestinal ulcers. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. When used in combination with anticholinergics (such as atropine) for a long time, it can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by this product. 7. When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be appropriately adjusted because this product can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase the metabolic clearance rate of this product, so when used in combination with thyroid hormones or antithyroid drugs, the dosage of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, the therapeutic effects and adverse reactions of this product can be enhanced. 10. When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. 11. When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12. When used in combination with ephedrine, its metabolic clearance can be enhanced. 13. When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14. It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15. It can promote the metabolism of mexiletine in the body and reduce its blood concentration. 16. When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17. When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.

Keep away from light and store in a sealed container.

2ml:10mg

36 months

Sinopharm Ronshyn Pharmaceutical Co., Ltd.

• Founded in:

  1999-05-06

• Address:

  No. 686, Yingbin Avenue, Wuzhi County, Jiaozuo City, Henan Province

• Tax NO.:

  914108237156088969

• Registered Funds:

  150 million yuan

• Email:

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