Sodium Chloride Injection

Sodium chloride is an electrolyte supplement. Sodium and chloride are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the plasma sodium content plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. Sodium and chloride ions in the human body are mainly regulated by the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure.

This product is an isotonic sterile aqueous solution of sodium chloride. The sodium chloride (NaCl) content should be 0.850% to 0.950% (g/ml).

This product is a colorless, clear liquid with a slightly salty taste.

Water loss due to various reasons includes hypotonic, isotonic and hypertonic water loss; hypertonic non-ketotic diabetic coma can be corrected by using isotonic or hypotonic sodium chloride; hypochloremic metabolic alkalosis; external use of normal saline to wash eyes and wounds, etc.; also used for water bag induction in obstetrics

1. Hypertonic dehydration: When patients have hypertonic dehydration, the osmotic concentration of brain cells and cerebrospinal fluid increases. If the treatment causes the sodium concentration and osmotic concentration of plasma and extracellular fluid to drop too quickly, it may cause cerebral edema. Therefore, it is generally believed that the plasma sodium concentration should not drop by more than 0.5mmol/L per hour within 48 hours after the start of treatment. If the patient is in shock, sodium chloride injection should be given first and colloid should be supplemented as appropriate. When the shock is corrected, if the blood sodium is 155mmol/L and the plasma osmotic concentration is 350mOsm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration is <330mOsm/L, 0.9% sodium chloride injection can be used instead. The total amount of fluid replacement is calculated according to the following formula as a reference: The required amount of fluid replacement (L) = [blood sodium concentration (mmol/L)] l/L)-142]×0.6×body weight (Kg)÷blood sodium concentration (mmol/L)Usually, half of the amount is replenished on the first day, and the rest is replenished within the next 2-3 days and adjusted according to cardiopulmonary and renal function. 2 Isotonic dehydration: In principle, isotonic solutions such as 0.9% sodium chloride injection or compound sodium chloride injection are given. However, the chloride concentration of the above solutions is significantly higher than that of plasma. Large amounts of use alone can cause hyperchloremia. Therefore, 0.9% sodium chloride injection and 1.25% sodium bicarbonate or 1.86% (1/6M) sodium lactate can be prepared in a ratio of 7:3 and then replenished. The chloride concentration of the latter is 107mmol/L and can correct metabolic acidosis. The amount of replenishment can be calculated according to body weight or hematocrit as a reference. ① Calculate according to body weight: Fluid replacement ② Calculated by hematocrit: Fluid replacement volume (L) = (actual hematocrit - normal hematocrit) × body weight (kg) × 0.2 / normal hematocrit Normal hematocrit is 48% for men and 42% for women 3 Hypotonic dehydration: In severe hypotonic dehydration, the amount of solutes in brain cells decreases to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentrations and osmotic concentrations to rise rapidly, brain cell damage may occur. It is generally believed that when blood sodium is lower than 120mmol/L, treatment should be used to increase blood sodium by 0.5mmol/L per hour and not more than 1.5mmol/L per hour. When blood sodium is lower than 120mmol/L or out When central nervous system symptoms occur, 3%-5% sodium chloride injection can be slowly dripped. Generally, it is required to increase the blood sodium concentration to above 120mmol/L within 6 hours. The amount of sodium supplement (mmol) = [142-actual blood sodium concentration (mmol/L)] × body weight (kg) × 0.2. When the blood sodium rises to above 120-125mmol/L, isotonic solution can be used instead, or hypertonic glucose injection or 10% sodium chloride injection can be added to the isotonic solution as appropriate. 4. Hypochloremic alkalosis: 0.9% sodium chloride injection or compound sodium chloride injection (Ringer's solution) 500-1000ml is given. The dosage is determined according to the alkalosis situation. 5. For external use, wash the wound and rinse the eyes with physiological sodium chloride solution.

1. Too much or too fast infusion can cause water and sodium retention, resulting in edema, increased blood pressure, increased heart rate, chest tightness, dyspnea and even acute left heart failure. 2. Too much or too fast administration of hypotonic sodium chloride can cause hemolysis, cerebral edema, etc.

Contraindicated in pregnancy induced hypertension

Precautions for children: The amount and speed of fluid replacement for children should be strictly controlled. Precautions for pregnancy and lactation: Contraindicated for pregnancy-induced hypertension syndrome. Precautions for the elderly: The amount and speed of fluid replacement for the elderly should be strictly controlled. Elderly people with impaired heart function should use with caution.

When used as a drug solvent or diluent, attention should be paid to the incompatibility between drugs

Keep tightly closed.

10 ml: 90 mg

24 months

Sinopharm Ronshyn Pharmaceutical Co., Ltd.

• Founded in:

  1999-05-06

• Address:

  No. 686, Yingbin Avenue, Wuzhi County, Jiaozuo City, Henan Province

• Tax NO.:

  914108237156088969

• Registered Funds:

  150 million yuan

• Email:

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